Helicobacter pylori Infection is Associated with Occurrence of Proteinuria in Type 2 Diabetes Patients: A Systemic Review and Meta-Analysis Translated title: 2型糖尿病患者出现蛋白尿和幽门螺旋杆菌感染的联 系：荟萃分析

Abstract

Background:

Type 2 diabetes (T2DM) patients are susceptible to Helicobacter pylori (HP), and it has been reported that the occurrence of proteinuria is associated with HP infection in T2DM patients; however, this view remains controversial. This meta-analysis aimed to explore the association between HP infection and the occurrence of proteinuria in T2DM patients. In addition, we hope to provide some recommendations to readers in clinical or related fields.

Methods:

Our meta-analysis was conducted with the methodology of the Cochrane Collaboration. Search strategies were formulated by relevant professionals. Case–control studies that compared the occurrence of proteinuria in T2DM patients with and without HP infection were involved in our meta-analysis. Relevant English or Chinese studies were searched on online databases before 2018, including PubMed, the Cochrane library, Medline, Google Scholar, the China National Infrastructure, and Wanfang database. The search strategies were “diabetic proteinuria, diabetic microalbuminuria, diabetic albuminuria, diabetic kidney disease, diabetic renal dysfunction, diabetic renal disease, diabetic nephropathy, diabetic complications, and diabetic mellitus, combined with HP.” The quality of these involved articles was separately assessed by two investigators using the Newcastle–Ottawa Scale (NOS). Odds ratios ( ORs) and associated 95% confidence intervals ( CIs) were extracted and pooled using fixed-effects models.

Results:

Seven studies involving 1029 participants were included. The quality of these seven articles was all above five stars as assessed by NOS, and there was no significant publication bias in our meta-analysis. We found that T2DM patients with HP infection had a 2.00 times higher risk of the occurrence of proteinuria than patients without HP infection ( OR: 2.00, 95% CI: 1.48–2.69).

Conclusions:

Our analysis showed that HP infection was associated with the occurrence of proteinuria in T2DM patients. HP radical surgery might be a therapeutic option for protecting kidney function in patients with T2DM.

摘要

背景：

2型糖尿病患者易出现幽门螺旋杆菌感染，并且有学者报道2型糖尿病患者出现蛋白尿和幽门螺旋杆菌感染有关，但此 观点仍然存在争议。

目的：

本荟萃分析的目的主要是探求2型糖尿病肾病患者出现蛋白尿和幽门螺旋杆菌感染的关系，并为临床工作者及相关学 者提供建议。

方法：

本荟萃分析纳入与2型糖尿病患者出现蛋白尿和HP感染有关的病例对照研究。在以下数据库搜索了2018年以前的英文 或中文研究：Pubmed，Cochrane图书馆，Medline，谷歌学术，中国知网（CNKI）和万方数据库，检索策略为：糖尿病蛋白 尿，糖尿病微量白蛋白尿，糖尿病白蛋白尿，糖尿病肾病，糖尿病肾功能不全，糖尿病并发症和糖尿病，分别结合幽门螺旋 杆菌。纳入文章的质量由2名实验人员分别使用NOS量表进行评估。 本研究采用固定效应模型分析整合相关数据。

结果：

本荟萃分析纳入了7个病例对照研究共1029名参与者。7个病例对照研究的NOS评分均超过5颗星，且没有显著的发表偏 倚。分析结果显示，2型糖尿病患者合并幽门螺旋杆菌感染出现蛋白尿的风险是无幽门螺旋杆菌感染者的2倍（OR=2.00，95%CI (1.48，2.69)）。

结论：

本荟萃分析结果提示2型糖尿病患者出现蛋白尿和幽门螺旋杆菌的感染有关，幽门螺旋杆菌根治术可能是保护合并幽门 螺旋杆菌感染的糖尿病患者肾功能的有效方法。