Molecular Mechanism of Cannabinoids in Cancer Progression

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Cannabinoids are a family of heterogeneous compounds that mostly interact with receptors eliciting several physiological effects both in the central and peripheral nervous systems and in peripheral organs. They exert anticancer action by modulating signaling pathways involved in cancer progression; furthermore, the effects induced by their use depend on both the type of tumor and their action on the components of the endocannabinoid system. This review will explore the mechanism of action of the cannabinoids in signaling pathways involved in cancer proliferation, neovascularisation, migration, invasion, metastasis, and tumor angiogenesis.

Related collections

Most cited references 120

Record: found
Abstract: not found
Article: not found

Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

Y GAONI, R Mechoulam (1964)

0 comments Cited 429 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis.

Daniel Nomura, Jonathan Long, Sherry Niessen … (2010)

Tumor cells display progressive changes in metabolism that correlate with malignancy, including development of a lipogenic phenotype. How stored fats are liberated and remodeled to support cancer pathogenesis, however, remains unknown. Here, we show that the enzyme monoacylglycerol lipase (MAGL) is highly expressed in aggressive human cancer cells and primary tumors, where it regulates a fatty acid network enriched in oncogenic signaling lipids that promotes migration, invasion, survival, and in vivo tumor growth. Overexpression of MAGL in nonaggressive cancer cells recapitulates this fatty acid network and increases their pathogenicity-phenotypes that are reversed by an MAGL inhibitor. Impairments in MAGL-dependent tumor growth are rescued by a high-fat diet, indicating that exogenous sources of fatty acids can contribute to malignancy in cancers lacking MAGL activity. Together, these findings reveal how cancer cells can co-opt a lipolytic enzyme to translate their lipogenic state into an array of protumorigenic signals. PAPERFLICK:

0 comments Cited 317 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: found

Is Open Access

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

Shenglong Zou, Ujendra Kumar (2018)

The biological effects of cannabinoids, the major constituents of the ancient medicinal plant Cannabis sativa (marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2. The CB1R is the prominent subtype in the central nervous system (CNS) and has drawn great attention as a potential therapeutic avenue in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases. Furthermore, cannabinoids also modulate signal transduction pathways and exert profound effects at peripheral sites. Although cannabinoids have therapeutic potential, their psychoactive effects have largely limited their use in clinical practice. In this review, we briefly summarized our knowledge of cannabinoids and the endocannabinoid system, focusing on the CB1R and the CNS, with emphasis on recent breakthroughs in the field. We aim to define several potential roles of cannabinoid receptors in the modulation of signaling pathways and in association with several pathophysiological conditions. We believe that the therapeutic significance of cannabinoids is masked by the adverse effects and here alternative strategies are discussed to take therapeutic advantage of cannabinoids.

0 comments Cited 286 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Eberhard Schlicker: Role: Academic Editor

Journal

Journal ID (nlm-ta): Int J Mol Sci

Journal ID (iso-abbrev): Int J Mol Sci

Journal ID (publisher-id): ijms

Title: International Journal of Molecular Sciences

Publisher: MDPI

ISSN (Electronic): 1422-0067

Publication date (Electronic): 01 April 2021

Publication date Collection: April 2021

Volume: 22

Issue: 7

Electronic Location Identifier: 3680

Affiliations

[1 ]Department of Molecular Medicine and Medical Biotechnology, University of Naples “Federico II”, Via Pansini 5, 80131 Naples, Italy; pagano.cris@ 123456gmail.com (C.P.); vanna.navarra@ 123456libero.it (G.N.); coppola.laura6@ 123456gmail.com (L.C.)

[2 ]Institute of Endocrinology and Experimental Oncology, IEOS CNR, Via Pansini 5, 80131 Naples, Italy

Author notes

[* ]Correspondence: maubiful@ 123456unina.it (M.B.); chiara.laezza@ 123456ieos.cnr.it (C.L.)

[†]

Contributed equally to this work.

Article

Publisher ID: ijms-22-03680

DOI: 10.3390/ijms22073680

PMC ID: 8037087

PubMed ID: 33916164

SO-VID: f7d4ae32-f340-4387-9d71-1dfc5b3cf170

License:

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/).

Molecular Mechanism of Cannabinoids in Cancer Progression

Read this article at

Abstract

Related collections

Bioscientifica Open Endocrinology

Most cited references 120

Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish

Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis.

Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

Author and article information

Contributors

Journal

Affiliations

Author notes

Article

History

Categories

Comments

Comment on this article

Similar content 772

Cited by 14

Most referenced authors 1,046