MicroRNA-520c-3p inhibits hepatocellular carcinoma cell proliferation and invasion through induction of cell apoptosis by targeting glypican-3.

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Abstract

Glypican-3 (GPC3) is a membrane-associated heparan sulfate proteoglycan involved in regulation of cell proliferation, cell survival, cell migration and differentiation process. MicroRNAs (miRNAs) are single-stranded, non-coding functional RNAs that are important in many biological processes. GPC3 and miRNAs have been found to play essential roles in the development and progression of hepatocellular carcinoma (HCC). However, little information about the relationship between GPC3 and miRNAs is available nowadays. Therefore, this study aims to examine the relationship between GPC3 and miRNAs.

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Author and article information

Journal

Journal ID (iso-abbrev): Hepatol. Res.

Title: Hepatology research : the official journal of the Japan Society of Hepatology

Publisher: Wiley-Blackwell

ISSN: 1386-6346

ISSN (Print): 1386-6346

Publication date (Electronic): Mar 2014

Volume: 44

Issue: 3

Affiliations

[1 ] Department of General Surgery, The First Clinical Medical School of Jinan University, Guangzhou, China; Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China.

Article

DOI: 10.1111/hepr.12121

PubMed ID: 23607462

SO-VID: fb74adc6-74f5-4062-8437-3d00d118429a

History

Keywords: glypican-3,hepatocellular carcinoma,miR-520c-3p

Data availability:

Keywords: glypican-3, hepatocellular carcinoma, miR-520c-3p

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