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Mechanoenergetic effects of pimobendan in canine left ventricles. Comparison with dobutamine.
K Hata
1 ,
Y Goto ,
S Futaki ,
Y Ohgoshi ,
H Yaku ,
O Kawaguchi ,
T Takasago ,
A Saeki ,
T W Taylor ,
T Nishioka
Oct 1992
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Abstract
We hypothesized that the effect of pimobendan (UD-CG 115 BS) to increase calcium sensitivity of contractile protein might result in less myocardial oxygen consumption (VO2) in comparison with dobutamine when they enhance ventricular contractility to the same extent. To examine this hypothesis, we compared the effects of pimobendan and dobutamine on left ventricular contractility and energetics using the frameworks of Emax (contractility index) and the relation between VO2 and PVA (systolic pressure-volume area, a measure of left ventricular total mechanical energy).