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      Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.

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          Abstract

          A recent cluster of pneumonia cases in Wuhan, China, was caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV). We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients.

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          Most cited references4

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          Middle East Respiratory Syndrome Coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group

          Journal of Virology, 87(14), 7790-7792
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            Corticosteroids as adjunctive therapy in the treatment of influenza.

            Specific treatments for influenza are limited to neuraminidase inhibitors and adamantanes. Corticosteroids show evidence of benefit in sepsis and related conditions, most likely due to their anti-inflammatory and immunomodulatory properties. Although commonly prescribed for severe influenza, there is uncertainty over their potential benefits or harms. This is an update of a review first published in 2016.
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              Bats as animal reservoirs for the SARS coronavirus: Hypothesis proved after 10 years of virus hunting

              Recently, the team led by Dr. Zhengli Shi from Wuhan Institute of Virology, Chinese Academy of Sciences, and Dr. Peter Daszak from Ecohealth Alliance identified SL-CoVs in Chinese horseshoe bats that were 95% identical to human SARS-CoV and were able to use human angiotensin-converting enzyme 2 (ACE2) receptor for docking and entry. Remarkably, they isolated the first known live bat SL-CoV that replicates in human and related cells. Their findings provide clear evidence that some SL-CoVs circulating in bats are capable of infecting and replicating in human (Ge X Y, et al., 2013).
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                Author and article information

                Journal
                Lancet
                Lancet (London, England)
                Elsevier BV
                1474-547X
                0140-6736
                February 15 2020
                : 395
                : 10223
                Affiliations
                [1 ] Jin Yin-tan Hospital, Wuhan, China.
                [2 ] Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Department of Respiratory Medicine, Capital Medical University, Beijing, China.
                [3 ] Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
                [4 ] NHC Key Laboratory of Systems Biology of Pathogens and Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
                [5 ] Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
                [6 ] Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
                [7 ] Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
                [8 ] Tsinghua University School of Medicine, Beijing, China.
                [9 ] Department of Respiratory medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
                [10 ] Department of Radiology, China-Japan Friendship Hospital, Beijing, China.
                [11 ] Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
                [12 ] Department of Pulmonary and Critical Care Medicine, Peking University First Hospital, Beijing, China.
                [13 ] Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, China.
                [14 ] NHC Key Laboratory of Systems Biology of Pathogens and Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address: wangjw28@163.com.
                [15 ] Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Department of Respiratory Medicine, Capital Medical University, Beijing, China; Tsinghua University-Peking University Joint Center for Life Sciences, Beijing, China. Electronic address: caobin_ben@163.com.
                Article
                S0140-6736(20)30183-5
                10.1016/S0140-6736(20)30183-5
                7159299
                31986264
                9cf0e170-d24a-4efe-bd86-eb4a766611f4
                Copyright © 2020 Elsevier Ltd. All rights reserved.
                History

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