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Abstract
<p class="first" id="P1">Atherosclerosis is a multifactorial disease that preferentially
occurs in arterial
regions exposed to disturbed blood flow (d-flow). The mechanisms by which d-flow induces
atherosclerosis involve changes in the transcriptome, methylome, proteome, and metabolome
of multiple vascular cells, especially endothelial cells. Initially, we begin with
the pathogenesis of atherosclerosis and the changes that occur at multiple levels
owing to d-flow, especially in the endothelium. Also, there are a variety of strategies
used for the global profiling of the genome, transcriptome, miRNA-nome, DNA methylome,
and metabolome that are important to define the biological and pathophysiological
mechanisms of endothelial dysfunction and atherosclerosis. Finally, systems biology
can be used to integrate these ‘omics’ datasets, especially those that derive data
based on a single animal model, in order to better understand the pathophysiology
of atherosclerosis development in a holistic manner and how this integrative approach
could be used to identify novel molecular diagnostics and therapeutic targets to prevent
or treat atherosclerosis.
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