Free water improves detection of changes in the substantia nigra in parkinsonism: A multisite study.

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Abstract

Imaging markers that are sensitive to parkinsonism across multiple sites are critically needed for clinical trials. The objective of this study was to evaluate changes in the substantia nigra using single- and bi-tensor models of diffusion magnetic resonance imaging in PD, MSA, and PSP.

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Author and article information

Journal

Journal ID (iso-abbrev): Mov. Disord.

Title: Movement disorders : official journal of the Movement Disorder Society

Publisher: Wiley

ISSN (Electronic): 1531-8257

ISSN (Print): 0885-3185

Publication date (Electronic): Oct 2017

Volume: 32

Issue: 10

Affiliations

[1 ] Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.

[2 ] Department of Neuroradiology, Medical University Innsbruck, Innsbruck, Austria.

[3 ] Departments of Psychiatry and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

[4 ] Department of Neurology, Penn State - Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.

[5 ] Department of Pharmacology, Penn State - Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.

[6 ] Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, USA.

[7 ] Department of Neurology, University of Florida, Gainesville, Florida, USA.

[8 ] Department of Neurosurgery, University of Florida, Gainesville, Florida, USA.

[9 ] Neuroimaging Research Core Facility, Medical University Innsbruck, Innsbruck, Austria.

[10 ] Department of Public Health Sciences, Medical College of South Carolina, Charleston, South Carolina, USA.

[11 ] Departments of Neurosurgery, Radiology, and Kinesiology, Penn State - Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.

[12 ] Department of Biomedical Engineering, University of Florida, Gainesville, Florida, USA.

Article

Mid ID: NIHMS923584

DOI: 10.1002/mds.27100

PMC ID: 5718046

PubMed ID: 28714593

SO-VID: 8e658cb4-28b4-41e6-8ff6-803798eb382a

History

Keywords: midbrain,dopamine,diffusion imaging,cell,substantia nigra

Data availability:

Keywords: midbrain, dopamine, diffusion imaging, cell, substantia nigra

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