Epigenetic aging in older breast cancer survivors and noncancer controls: preliminary findings from the Thinking and Living with Cancer Study.

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Abstract

Cancer and its treatments may accelerate aging in survivors; however, research has not examined epigenetic markers of aging in longer term breast cancer survivors. This study examined whether older breast cancer survivors showed greater epigenetic aging than noncancer controls and whether epigenetic aging related to functional outcomes.

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Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

Yoav Benjamini, Yosef Hochberg (1995)

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Journal

Journal ID (iso-abbrev): Cancer

Title: Cancer

Publisher: Wiley

ISSN (Electronic): 1097-0142

ISSN (Print): 0008-543X

Publication date (Electronic): Sep 01 2023

Volume: 129

Issue: 17

Affiliations

[1 ] Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

[2 ] Norman Cousins Center for Psychoneuroimmunology, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.

[3 ] Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California, USA.

[4 ] Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.

[5 ] School of Aging Studies, University of South Florida, Tampa, Florida, USA.

[6 ] Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

[7 ] Department of Biostatistics, Bioinformatics, and Biomathematics, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.

[8 ] Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, USA.

[9 ] Moffitt Cancer Center, University of South Florida, Tampa, Florida, USA.

[10 ] John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, New Jersey, USA.

[11 ] Department of Radiology and Imaging Sciences, Indiana University School of Medicine and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, USA.

[12 ] Department of Psychiatry, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.

[13 ] City of Hope National Medical Center, Los Angeles, California, USA.

Article

Mid ID: NIHMS1941984

DOI: 10.1002/cncr.34818

PMC ID: 10659047

PubMed ID: 37259669

SO-VID: 8c5a062c-9093-494f-9023-6e33f0691bd7

History

Keywords: breast cancer,DNA methylation,biological aging,physical function,older adults,epigenetic clock,cognitive function

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Keywords: breast cancer, DNA methylation, biological aging, physical function, older adults, epigenetic clock, cognitive function

Epigenetic aging in older breast cancer survivors and noncancer controls: preliminary findings from the Thinking and Living with Cancer Study.

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Abstract

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Cancer Metabolism

Most cited references 1

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

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