ABCB1 polymorphisms are associated with cyclosporine-induced nephrotoxicity and gingival hyperplasia in renal transplant recipients.

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Abstract

There is a great deal of controversy regarding the clinical impact of genetic variants in patients receiving cyclosporine (CsA) as immunosuppressant therapy. We have investigated the effect of polymorphisms in the CYP3A and ABCB1 genes on CsA pharmacokinetics, acute rejection incidence and drug-related side effects in renal transplant recipients

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Journal

Journal ID (iso-abbrev): Eur. J. Clin. Pharmacol.

Title: European journal of clinical pharmacology

ISSN (Electronic): 1432-1041

ISSN (Print): 0031-6970

Publication date (Electronic): Mar 2013

Volume: 69

Issue: 3

Affiliations

[1 ] Department of Surgical and Medical Therapeutics, Division of Pharmacology, Medical School, University of Extremadura, Av. Elvas s/n 06071, Badajoz, Spain.

Article

DOI: 10.1007/s00228-012-1355-x

PubMed ID: 22886152

SO-VID: 01a3034b-6377-4731-9d0d-69a6e50cd1b5

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