Relationship between MRGPRX2 and pethidine hydrochloride- or fentanyl citrate-induced LAD2 cell degranulation.

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Abstract

Pethidine hydrochloride (PH) and fentanyl citrate (FC) are opioid receptor agonists commonly used to treat pain clinically. PH and FC have been reported to have a high potential for pseudoallergic effects, but the underlying mechanism has not been well studied. MRGPRX2 is a novel atypical opioid receptor that is mainly expressed in human mast cells and considered to mediate drug-induced pseudoallergic reactions. This study aimed to investigate the allergy effect of these two opioid receptor agonists and the possible association of MRGPRX2 with this response.

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Author and article information

Journal

Journal ID (iso-abbrev): J Pharm Pharmacol

Title: The Journal of pharmacy and pharmacology

Publisher: Wiley

ISSN (Electronic): 2042-7158

ISSN (Print): 0022-3573

Publication date (Electronic): Dec 2018

Volume: 70

Issue: 12

Affiliations

[1 ] School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.

Article

DOI: 10.1111/jphp.13009

PubMed ID: 30256417

SO-VID: 01b194f3-f356-4ea8-8f96-5154cf564d5a

History

Keywords: MRGPRX2,degranulation,fentanyl,mast cells,pethidine

Data availability:

Keywords: MRGPRX2, degranulation, fentanyl, mast cells, pethidine

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