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      Recent Advances and Challenges towards Sustainable Polyhydroxyalkanoate (PHA) Production

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          Abstract

          Sustainable biofuels, biomaterials, and fine chemicals production is a critical matter that research teams around the globe are focusing on nowadays. Polyhydroxyalkanoates represent one of the biomaterials of the future due to their physicochemical properties, biodegradability, and biocompatibility. Designing efficient and economic bioprocesses, combined with the respective social and environmental benefits, has brought together scientists from different backgrounds highlighting the multidisciplinary character of such a venture. In the current review, challenges and opportunities regarding polyhydroxyalkanoate production are presented and discussed, covering key steps of their overall production process by applying pure and mixed culture biotechnology, from raw bioprocess development to downstream processing.

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          A microbial polyhydroxyalkanoates (PHA) based bio- and materials industry.

          Guo-Qiang Chen (2009)
          Biopolyesters polyhydroxyalkanoates (PHA) produced by many bacteria have been investigated by microbiologists, molecular biologists, biochemists, chemical engineers, chemists, polymer experts and medical researchers. PHA applications as bioplastics, fine chemicals, implant biomaterials, medicines and biofuels have been developed and are covered in this critical review. Companies have been established or involved in PHA related R&D as well as large scale production. Recently, bacterial PHA synthesis has been found to be useful for improving robustness of industrial microorganisms and regulating bacterial metabolism, leading to yield improvement on some fermentation products. In addition, amphiphilic proteins related to PHA synthesis including PhaP, PhaZ or PhaC have been found to be useful for achieving protein purification and even specific drug targeting. It has become clear that PHA and its related technologies are forming an industrial value chain ranging from fermentation, materials, energy to medical fields (142 references).
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            Polyhydroxyalkanoate (PHA): Review of synthesis, characteristics, processing and potential applications in packaging

            A. Lazzeri, P Cinelli, E. Bugnicourt … (2014)
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              Aqueous two-phase system (ATPS): an overview and advances in its applications

              Mujahid Iqbal, Yanfei Tao, Shuyu Xie … (2016)
              Aqueous two-phase system (ATPS) is a liquid-liquid fractionation technique and has gained an interest because of great potential for the extraction, separation, purification and enrichment of proteins, membranes, viruses, enzymes, nucleic acids and other biomolecules both in industry and academia. Although, the partition behavior involved in the method is complex and difficult to predict. Current research shows that it has also been successfully used in the detection of veterinary drug residues in food, separation of precious metals, sewage treatment and a variety of other purposes. The ATPS is able to give high recovery yield and is easily to scale up. It is also very economic and environment friendly method. The aim of this review is to overview the basics of ATPS, optimization and its applications.
              Article 0 comments Cited 140 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Martin Koller: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Bioengineering (Basel)
                Journal ID (iso-abbrev): Bioengineering (Basel)
                Journal ID (publisher-id): bioengineering
                Title: Bioengineering
                Publisher: MDPI
                ISSN (Electronic): 2306-5354
                Publication date (Electronic): 11 June 2017
                Publication date Collection: June 2017
                Volume: 4
                Issue: 2
                Electronic Location Identifier: 55
                Affiliations
                [1 ]UCIBIO-REQUIMTE, Department of Chemistry, Faculdade de Ciências e Tecnologia/Universidade Nova de Lisboa, 2829-516 Caparica, Portugal; amr@ 123456fct.unl.pt
                [2 ]Centre for Cytochrome P450 Biodiversity, Institute of Life Science, Swansea University Medical School, Singleton Park, Swansea SA2 8PP, UK; j.e.placidoescobar@ 123456swansea.ac.uk
                [3 ]Faculty of Engineering and the Environment, University of Southampton, Highfield, Southampton SO17 1BJ, UK; n.venetsaneas@ 123456aston.ac.uk
                [4 ]European Bioenergy Research Institute (EBRI), Aston University, Aston Triangle, Birmingham B4 7ET, UK
                [5 ]Department of Chemical and Biochemical Engineering, Center for Bioprocess Engineering, Søltofts Plads, Technical University of Denmark, Building 229, 2800 Kgs. Lyngby, Denmark; afig@ 123456kt.dtu.dk (A.B.-F.); cvar@ 123456kt.dtu.dk (C.V.); hnga@ 123456kt.dtu.dk (H.N.G.)
                Author notes
                [* ]Correspondence: ckourmentza@ 123456gmail.com or c.kourmentza@ 123456fct.unl.pt ; Tel.: +351-917-900-929
                Article
                Publisher ID: bioengineering-04-00055
                DOI: 10.3390/bioengineering4020055
                PMC ID: 5590474
                PubMed ID: 28952486
                SO-VID: 03871c69-6335-4a3b-8101-b9b2936ffdef
                Copyright © © 2017 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 30 April 2017
                Date accepted : 09 June 2017
                Categories
                Subject: Review

                Keywords: polyhydroxyalkanoates,biopolymers,renewable feedstock,mixed microbial consortia,enrichment strategy,pure cultures,synthetic biology,downstream processing
                Data availability:
                Keywords: polyhydroxyalkanoates, biopolymers, renewable feedstock, mixed microbial consortia, enrichment strategy, pure cultures, synthetic biology, downstream processing

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