For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
151
views
126
references
 Top references
cited by
114
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      1,051
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: not found

      Adult mesenchymal stem cells and cell-based tissue engineering

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The identification of multipotential mesenchymal stem cells (MSCs) derived from adult human tissues, including bone marrow stroma and a number of connective tissues, has provided exciting prospects for cell-based tissue engineering and regeneration. This review focuses on the biology of MSCs, including their differentiation potentials in vitro and in vivo, and the application of MSCs in tissue engineering. Our current understanding of MSCs lags behind that of other stem cell types, such as hematopoietic stem cells. Future research should aim to define the cellular and molecular fingerprints of MSCs and elucidate their endogenous role(s) in normal and abnormal tissue functions.

          Related collections

          Most cited references126

          • Record: found
          • Abstract: found
          • Article: not found

          TGF-beta signal transduction.

          J Massagué (1998)
          The transforming growth factor beta (TGF-beta) family of growth factors control the development and homeostasis of most tissues in metazoan organisms. Work over the past few years has led to the elucidation of a TGF-beta signal transduction network. This network involves receptor serine/threonine kinases at the cell surface and their substrates, the SMAD proteins, which move into the nucleus, where they activate target gene transcription in association with DNA-binding partners. Distinct repertoires of receptors, SMAD proteins, and DNA-binding partners seemingly underlie, in a cell-specific manner, the multifunctional nature of TGF-beta and related factors. Mutations in these pathways are the cause of various forms of human cancer and developmental disorders.
          Article 0 comments Cited 683 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Electrospun nanofibrous structure: A novel scaffold for tissue engineering

            Wan-Ju Li, Frank Ko, Rocky S Tuan … (2002)
            The architecture of an engineered tissue substitute plays an important role in modulating tissue growth. A novel poly(D,L-lactide-co-glycolide) (PLGA) structure with a unique architecture produced by an electrospinning process has been developed for tissue-engineering applications. Electrospinning is a process whereby ultra-fine fibers are formed in a high-voltage electrostatic field. The electrospun structure, composed of PLGA fibers ranging from 500 to 800 nm in diameter, features a morphologic similarity to the extracellular matrix (ECM) of natural tissue, which is characterized by a wide range of pore diameter distribution, high porosity, and effective mechanical properties. Such a structure meets the essential design criteria of an ideal engineered scaffold. The favorable cell-matrix interaction within the cellular construct supports the active biocompatibility of the structure. The electrospun nanofibrous structure is capable of supporting cell attachment and proliferation. Cells seeded on this structure tend to maintain phenotypic shape and guided growth according to nanofiber orientation. This novel biodegradable scaffold has potential applications for tissue engineering based upon its unique architecture, which acts to support and guide cell growth. Copyright 2002 Wiley Periodicals, Inc. J Biomed Mater Res 60: 613-621, 2002
            Article 0 comments Cited 430 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.

              Yaoqin Gong, Roger B Slee, Naomi Fukai … (2001)
              In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass accrual during growth. Mutations in LRP5 cause the autosomal recessive disorder osteoporosis-pseudoglioma syndrome (OPPG). We find that OPPG carriers have reduced bone mass when compared to age- and gender-matched controls. We demonstrate LRP5 expression by osteoblasts in situ and show that LRP5 can transduce Wnt signaling in vitro via the canonical pathway. We further show that a mutant-secreted form of LRP5 can reduce bone thickness in mouse calvarial explant cultures. These data indicate that Wnt-mediated signaling via LRP5 affects bone accrual during growth and is important for the establishment of peak bone mass.
              Article 0 comments Cited 403 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Arthritis Res Ther
                Title: Arthritis Research & Therapy
                Publisher: BioMed Central (London )
                ISSN (Print): 1478-6354
                ISSN (Electronic): 1478-6362
                Publication date (Print): 2003
                Publication date (Electronic): 11 December 2002
                Volume: 5
                Issue: 1
                Pages: 32-45
                Affiliations
                [1 ]Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA
                Article
                Publisher ID: ar614
                DOI: 10.1186/ar614
                PMC ID: 154434
                PubMed ID: 12716446
                SO-VID: 06cf3be1-dfda-4b32-b518-6766d01b0858
                Copyright © Copyright © 2003 BioMed Central Ltd
                History
                Date received : 7 October 2002
                Date accepted : 1 November 2002
                Categories
                Subject: Review

                ScienceOpen disciplines: Orthopedics
                Keywords: tissue engineering,cell signaling,stem cells,mesenchymal stem cells,cell differentiation
                Data availability:
                ScienceOpen disciplines: Orthopedics
                Keywords: tissue engineering, cell signaling, stem cells, mesenchymal stem cells, cell differentiation

                Comments

                Comment on this article

                scite_

                Similar content1,051

                See all similar

                Cited by114

                See all cited by

                Most referenced authors3,046

                See all reference authors