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The cannabinoid receptor: biochemical, anatomical and behavioral characterization
Allyn C Howlett ,
Michelle Bidaut-Russell ,
William A Devane ,
Lawrence S Melvin ,
M.Ross Johnson ,
Miles Herkenham
October 1990
October 1990
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Abstract
The actions of the active principle of marihuana, delta 9-tetrahydrocannabinol, are
mimicked by synthetic cannabinoid agonists showing high potency and enantio-selectivity
in behavioral assays. These drugs have been used to characterize cannabinoid receptor
binding, biochemistry and pharmacology, leading to a better understanding of the effects
of cannabinoids in the CNS of humans and experimental animals.