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      Peroxynitrite Induces Formation of N -(Carboxymethyl)Lysine by the Cleavage of Amadori Product and Generation of Glucosone and Glyoxal From Glucose: Novel Pathways for Protein Modification by Peroxynitrite

      , , , , , ,

      Diabetes

      American Diabetes Association

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          Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

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            Nitric oxide: an endogenous modulator of leukocyte adhesion.

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              Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking.

              Age-associated increases in collagen cross-linking and accumulation of advanced glycosylation products are both accelerated by diabetes, suggesting that glucose-derived cross-link formation may contribute to the development of chronic diabetic complications as well as certain physical changes of aging. Aminoguanidine, a nucleophilic hydrazine compound, prevented both the formation of fluorescent advanced nonenzymatic glycosylation products and the formation of glucose-derived collagen cross-links in vitro. Aminoguanidine administration to rats was equally effective in preventing diabetes-induced formation of fluorescent advanced nonenzymatic glycosylation products and cross-linking of arterial wall connective tissue protein in vivo. The identification of aminoguanidine as an inhibitor of advanced nonenzymatic glycosylation product formation now makes possible precise experimental definition of the pathogenetic significance of this process and suggests a potential clinical role for aminoguanidine in the future treatment of chronic diabetic complications.
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                Author and article information

                Journal
                Diabetes
                Diabetes
                American Diabetes Association
                0012-1797
                1939-327X
                September 01 2002
                September 01 2002
                : 51
                : 9
                : 2833-2839
                Article
                10.2337/diabetes.51.9.2833
                © 2002

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