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      Natural deep eutectic solvents as new potential media for green technology.

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          Abstract

          Developing new green solvents is one of the key subjects in Green Chemistry. Ionic liquids (ILs) and deep eutectic solvents, thus, have been paid great attention to replace current harsh organic solvents and have been applied to many chemical processing such as extraction and synthesis. However, current ionic liquids and deep eutectic solvents have still limitations to be applied to a real chemical industry due to toxicity against human and environment and high cost of ILs and solid state of most deep eutectic solvents at room temperature. Recently we discovered that many plant abundant primary metabolites changed their state from solid to liquid when they were mixed in proper ratio. This finding made us hypothesize that natural deep eutectic solvents (NADES) play a role as alternative media to water in living organisms and tested a wide range of natural products, which resulted in discovery of over 100 NADES from nature. In order to prove deep eutectic feature the interaction between the molecules was investigated by nuclear magnetic resonance spectroscopy. All the tested NADES show clear hydrogen bonding between components. As next step physical properties of NADES such as water activity, density, viscosity, polarity and thermal properties were measured as well as the effect of water on the physical properties. In the last stage the novel NADES were applied to the solubilization of wide range of biomolecules such as non-water soluble bioactive natural products, gluten, starch, and DNA. In most cases the solubility of the biomolecules evaluated in this study was greatly higher than water. Based on the results the novel NADES may be expected as potential green solvents at room temperature in diverse fields of chemistry.

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          Author and article information

          Journal
          Anal Chim Acta
          Analytica chimica acta
          Elsevier BV
          1873-4324
          0003-2670
          Mar 05 2013
          : 766
          Affiliations
          [1 ] Natural Products Laboratory, Institute of Biology, Leiden University, 2300 RA Leiden, The Netherlands.
          Article
          S0003-2670(12)01826-0
          10.1016/j.aca.2012.12.019
          23427801
          12a08b6a-a4d6-4e5c-8a70-04c5e848707c
          Copyright © 2012 Elsevier B.V. All rights reserved.
          History

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