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      Effect of Paeonol on Antioxidant and Immune Regulatory Activity in Hepatocellular Carcinoma Rats

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          Abstract

          The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results showed that paeonol significantly reduced the serum AST, ALT, ALP, GGT, AFU and liver MDA levels, increased serum WBC, TP, ALB, A/G, TNF-α and IFN-γ and liver antioxidant enzymes activities (SOD, CAT, GSH-Px, GR) in HCC rats. Altogether, these results suggest that the paeonol could effectively decrease oxidative injury and improve immunity function in HCC rats.

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          Selenium: biochemical role as a component of glutathione peroxidase.

          J Rotruck, A. Pope, H E Ganther … (1973)
          When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H(2)O(2), added glutathione failed to protect the hemoglobin from oxidative damage. This occurred because the erythrocytes were practically devoid of glutathione-peroxidase activity. Extensively purified preparations of glutathione peroxidase contained a large part of the (75)Se of erythrocytes labeled in vivo. Many of the nutritional effects of selenium can be explained by its role in glutathione peroxidase.
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            Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method.

            K Satoh (1978)
            A new colorimetric method for quantitative analysis of serum lipid peroxide, free of interference from sialic acids, has been developed. We have used the thiobarbituric acid dissolved in sodium sulfate solution and both liberation of lipid peroxide and color reaction have been performed simultaneously by heating serum protein precipitate with this reagent in a weak acid solution. The new method is specific and facilitates the precise measurements of serum lipid peroxide. The average values determined by the new method increased slightly with age in healthy subjects. In patients with sequelae of cerebrovascular disorders, serum lipid peroxide values were higher than in healthy controls. These results may demonstrate the important role of lipid peroxide in aging and cerebrovascular disorders.
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              Systemic therapy of advanced hepatocellular carcinoma: how hopeful should we be?

              Andrew Zhu (2006)
              Worldwide, hepatocellular carcinoma (HCC) is the fifth most common cancer and the third most common cause of cancer-related death. In the U.S., 18,510 new cancers of the liver and intrahepatic bile duct are expected in 2006, with an estimated 16,200 deaths. The incidence rates for HCC in the U.S. continued to rise steadily through 1998 and doubled during the period 1975-1995. Unresectable or metastatic HCC carries a poor prognosis, and systemic therapy with cytotoxic agents provides marginal benefit. A majority of HCC patients (>80%) presents with advanced or unresectable disease. Even for those with resected disease, the recurrence rate can be as high as 50% at 2 years. Because of the poor track record of systemic therapy in HCC, there has been a sense of nihilism for this disease in the oncology community for decades. However, with the arrival of newly developed molecularly targeted agents and the success of some of these agents in other traditionally challenging cancers, like renal cell carcinoma, there has recently been renewed interest in developing systemic therapy for HCC. This review attempts to concisely summarize the historical perspective and the current status of systemic therapy development in HCC.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Molecules
                Journal ID (iso-abbrev): Molecules
                Journal ID (publisher-id): molecules
                Title: Molecules
                Publisher: MDPI
                ISSN (Electronic): 1420-3049
                Publication date (Electronic): 20 April 2012
                Publication date Collection: April 2012
                Volume: 17
                Issue: 4
                Pages: 4672-4683
                Affiliations
                [1 ]Department of Fifth Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai 200438, China
                [2 ]Department of Hepatobiliary Surgery, The General Hospital of Ningxia Medical University, Yinchuan 750004, China
                [3 ]Department of Oncological Surgery, The General Hospital of Ningxia Medical University, Yinchuan 750004, China
                Author notes
                [* ] Author to whom correspondence should be addressed; Email: ghyangsjyd@ 123456sina.com ; Tel./Fax: +86-21-8187-5291.
                Article
                Publisher ID: molecules-17-04672
                DOI: 10.3390/molecules17044672
                PMC ID: 6268820
                PubMed ID: 22522397
                SO-VID: 12f49eb9-d21e-47e1-91a1-860f5b4d3ff4
                Copyright © © 2012 by the authors; licensee MDPI, Basel, Switzerland.
                License:

                This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/3.0/).

                History
                Date received : 08 March 2012
                Date revision received : 27 March 2012
                Date accepted : 05 April 2012
                Categories
                Subject: Article

                Keywords: hepatocellular carcinoma,paeonol,oxidative injury,immunity,diethyl-nitrosamine
                Data availability:
                Keywords: hepatocellular carcinoma, paeonol, oxidative injury, immunity, diethyl-nitrosamine

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