The Epigenetic Pathways to Ribosomal DNA Silencing.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Heterochromatin is the transcriptionally repressed portion of eukaryotic chromatin that maintains a condensed appearance throughout the cell cycle. At sites of ribosomal DNA (rDNA) heterochromatin, epigenetic states contribute to gene silencing and genome stability, which are required for proper chromosome segregation and a normal life span. Here, we focus on recent advances in the epigenetic regulation of rDNA silencing in Saccharomyces cerevisiae and in mammals, including regulation by several histone modifications and several protein components associated with the inner nuclear membrane within the nucleolus. Finally, we discuss the perturbations of rDNA epigenetic pathways in regulating cellular aging and in causing various types of diseases.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Microbiol. Mol. Biol. Rev.

Title: Microbiology and molecular biology reviews : MMBR

Publisher: American Society for Microbiology

ISSN (Electronic): 1098-5557

ISSN (Print): 1092-2172

Publication date (Electronic): September 2016

Volume: 80

Issue: 3

Affiliations

[1 ] Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan, Republic of Korea.

[2 ] Division of Molecular and Life Sciences, College of Science and Technology, Hanyang University, Ansan, Republic of Korea hoon320@hanyang.ac.kr.

Article

Publisher Item ID: 80/3/545

DOI: 10.1128/MMBR.00005-16

PMC ID: 4981667

PubMed ID: 27250769

SO-VID: 1c1d724d-2103-44cb-a6e7-38fda738fc55

History

Data availability:

Comments

Comment on this article

scite_

Cited by 31

See all cited by