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      Systemic Approach for Health Risk Assessment of Ambient Air Concentrations of Benzene in Petrochemical Environments: Integration of Fuzzy Logic, Artificial Neural Network, and IRIS Toxicity Method

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          Abstract

          Background:

          Reliable methods are crucial to cope with uncertainties in the risk analysis process. The aim of this study is to develop an integrated approach to assessing risks of benzene in the petrochemical plant that produces benzene. We offer an integrated system to contribute imprecise variables into the health risk calculation.

          Methods:

          The project was conducted in Asaluyeh, southern Iran during the years from 2013 to 2014. Integrated method includes fuzzy logic and artificial neural networks. Each technique had specific computational properties. Fuzzy logic was used for estimation of absorption rate. Artificial neural networks can decrease the noise of the data so applied for prediction of benzene concentration. First, the actual exposure was calculated then it combined with Integrated Risk Information System (IRIS) toxicity factors to assess real health risks.

          Results:

          High correlation between the measured and predicted benzene concentration was achieved (R 2= 0.941). As for variable distribution, the best estimation of risk in a population implied 33% of workers exposed less than 1×10 −5 and 67% inserted between 1.0×10 −5 to 9.8×10 −5 risk levels. The average estimated risk of exposure to benzene for entire work zones is equal to 2.4×10 −5, ranging from 1.5×10 −6 to 6.9×10 −5.

          Conclusion:

          The integrated model is highly flexible as well as the rules possibly will be changed according to the necessities of the user in a different circumstance. The measured exposures can be duplicated well through proposed model and realistic risk assessment data will be produced.

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          Most cited references10

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          Environmental exposure to benzene: an update.

          L. Wallace (1996)
          During the 1990s, several large-scale studies of benzene concentrations in air, food, and blood have added to our knowledge of its environmental occurrence. In general, the new studies have confirmed the earlier findings of the U.S. Environmental Protection Agency Total Exposure Assessment Methodology (TEAM) studies and other large-scale studies in Germany and the Netherlands concerning the levels of exposure and major sources. For example, the new studies found that personal exposures exceeded indoor concentrations of benzene, which in turn exceeded outdoor concentrations. The new studies of food concentrations have confirmed earlier indications that food is not an important pathway for benzene exposure. The results of the National Health and Nutrition Examination Survey on blood levels in a nationwide sample of 883 persons are in good agreement with the concentrations in exhaled breath measured in about 800 persons a decade earlier in the TEAM studies. Major sources of exposure continue to be active and passive smoking, auto exhaust, and driving or riding in automobiles. New methods in breath and blood sampling and analysis offer opportunities to investigate short-term peak exposures and resulting body burden under almost any conceivable field conditions.
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            Environmental and occupational exposure to benzene in Thailand.

            Exposure to benzene in air is a concern in Thailand, particularly since it was observed that the incidence of blood-related cancers, such as leukemia and lymphoma, has increased in the past few decades. In Bangkok, the mean atmospheric levels of benzene on main roads and in schools were 33.71 and 8.25 ppb, respectively, while in gasoline service stations and petrochemical factories the mean ambient levels were 64.78 and 66.24 ppb, respectively. Cloth vendors (22.61 ppb) and grilled-meat vendors (28.19 ppb) working on the roadsides were exposed to significantly higher levels of benzene than the control group (12.95 ppb; p<0.05). Bangkok school children (5.50 ppb) were exposed to significantly higher levels of benzene than provincial school children (2.54 ppb; p<0.01). Factory workers (73.55 ppb) and gasoline service attendants (121.67 ppb) were exposed to significantly higher levels of benzene than control workers (4.77 ppb; p<0.001). In accordance with the increased benzene exposures, levels of urinary trans,trans-muconic acid (MA) were significantly increased in all benzene-exposed groups. In school children, the levels of MA were relatively high, taking into account the much lower level of exposure. Blood benzene levels were also significantly increased in Bangkok school children (77.97 ppt; p<0.01), gasoline service attendants (641.84 ppt; p<0.05) and factory workers (572.61 ppt; p<0.001), when compared with the respective controls. DNA damage, determined as DNA strand breaks, was found to be elevated in gasoline service attendants, petrochemical factory workers, and Bangkok school children (p<0.001). The cytogenetic challenge assay, which measures DNA repair capacity, showed varying levels of significant increases in the numbers of dicentrics and deletions in gasoline service attendants, petrochemical factory workers and Bangkok school children, indicating a decrease in DNA repair capacity in these subjects.
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              Using doubly-labeled water measurements of human energy expenditure to estimate inhalation rates.

              Doubly-labeled water (DLW) data is recognized as an improvement over alternative methods to quantify human energy expenditure. Previously, energy expenditure has been estimated indirectly using heart-rate monitoring, calorimetry, or accelerometer measurements. Inhalation rate estimates can benefit from improved energy expenditure estimates using equations developed by Layton. DLW methods are advantageous for several reasons: the database is robust, they are direct measures, subjects are free-living, and the observation period is longer than what is possible from staged activity measures. DLW energy data is an improvement over previous inhalation estimates based on dietary recall survey data. Mean long-term inhalation rates of 16 m3/day and 13 m3/day, for physically active adult men and women, respectively, were derived based on DLW estimates of energy expended. The range of human energy expenditure is narrow with the maximum energy expenditure not likely greater than twice the minimum.
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                Author and article information

                Journal
                Iran J Public Health
                Iran. J. Public Health
                IJPH
                IJPH
                Iranian Journal of Public Health
                Tehran University of Medical Sciences
                2251-6085
                2251-6093
                September 2016
                : 45
                : 9
                : 1188-1198
                Affiliations
                [1. ] Safety and Environment, University of Tehran, Graduate Faculty of Environment, Tehran, Iran
                [2. ] Faculty of Environment, University of Tehran, Tehran, Iran
                Author notes
                [* ] Corresponding Author: Email: Givehchi@ 123456ut.ac.ir
                Article
                ijph-45-1188
                5149473
                27957464
                1c733749-8347-4121-952f-2af52d16df3d
                Copyright© Iranian Public Health Association & Tehran University of Medical Sciences

                This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

                History
                : 16 December 2015
                : 20 March 2016
                Categories
                Original Article

                Public health
                risk assessment,exposure estimation,benzene,cancer risk,fuzzy logic,neural network
                Public health
                risk assessment, exposure estimation, benzene, cancer risk, fuzzy logic, neural network

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