Long Non-Coding RNA KCNQ1OT1 Promotes Cataractogenesis via miR-214 and Activation of the Caspase-1 Pathway.

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Abstract

KCNQ1OT1 regulates the expression of tissue-specific imprinted genes within the Kcnq1 domain. Imprinted genes are positive regulators of apoptosis, one of the forms of cell death related to cataract formation, and thus may provide novel therapeutic targets for cataract treatment. Here, we studied the role of non-coding RNAs(ncRNA) in cataract formation.

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Author and article information

Journal

Journal ID (iso-abbrev): Cell. Physiol. Biochem.

Title: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Publisher: S. Karger AG

ISSN (Electronic): 1421-9778

ISSN (Print): 1015-8987

Publication date (Electronic): May 25 2017

Volume: 42

Issue: 1

Affiliations

[1 ] Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

[2 ] Department of Orthopedic, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Article

Publisher Item ID: 000477330

DOI: 10.1159/000477330

PubMed ID: 28535504

SO-VID: 1d15bd8c-b969-4e59-bbfe-21f2ada5d350

History

Keywords: Caspase-1,Cataract,KCNQ1OT1,Pyroptosis,miR-214

Data availability:

Keywords: Caspase-1, Cataract, KCNQ1OT1, Pyroptosis, miR-214

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