Chris Lauber:
ORCID: https://orcid.org/0000-0002-2265-2953
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
Project administrationRole: SoftwareRole: ValidationRole: VisualizationRole: Writing
– original draftRole: Writing – review & editing
Mathias J. Gerl:
ORCID: https://orcid.org/0000-0002-8074-7221
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
Writing – review & editing
Christian Klose:
ORCID: https://orcid.org/0000-0003-2853-4533
Role: Data curationRole: MethodologyRole: Writing – review & editing
Filip Ottosson:
ORCID: https://orcid.org/0000-0002-8312-3545
Role: ResourcesRole: Writing – review & editing
Olle Melander: Role: ResourcesRole: Writing – review & editing
Kai Simons: Role: ConceptualizationRole: InvestigationRole: Writing – original draftRole: Writing
– review & editing
Jason W. Locasale: Role: Academic Editor
Journal ID (nlm-ta): PLoS Biol
Journal ID (iso-abbrev): PLoS Biol
Journal ID (publisher-id): plos
Title:
PLoS Biology
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1544-9173
ISSN
(Electronic):
1545-7885
Publication date
(Electronic):
3
March
2022
Publication date Collection:
March
2022
Publication date PMC-release: 3
March
2022
Volume: 20
Issue: 3
Electronic Location Identifier: e3001561
Affiliations
[1
]
Lipotype GmbH, Dresden, Germany
[2
]
TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture
between the Hanover Medical School and the Helmholtz Centre for Infection Research,
Institute for Experimental Virology, Hanover, Germany
[3
]
Department of Clinical Sciences, Lund University, Malmö, Sweden
Duke University, UNITED STATES
Author notes
I have read the journal’s policy and the authors of this manuscript have the following
competing interests: KS is CEO of Lipotype GmbH. KS and CK are shareholders of Lipotype
GmbH. CL and MJG are employees of Lipotype GmbH.
Author information
Article
Publisher ID:
PBIOLOGY-D-21-01585
DOI: 10.1371/journal.pbio.3001561
PMC ID: 8893343
PubMed ID: 35239643
SO-VID: 22e53584-4143-459b-b90a-449ab7e2c04d
Copyright © © 2022 Lauber et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by:
Swedish Foundation for Strategic Research
Award ID: IRC LUDC
Award Recipient
:
Olle Melander
Funded by:
Swedish Research Council
Award ID: SFO-EXODIAB
Award Recipient
:
Olle Melander
Funded by:
Artificially Intelligent use of Registers at Lund University
Award ID: 2019-61406
Award Recipient
:
Olle Melander
Funded by:
Lund University Infrastructure Grants for population-based cohorts and metabolomics
platforms
Award ID: STYR 2019/2046
Award Recipient
:
Olle Melander
Funded by:
European Research Council
Award ID: AdG 2019-885003
Award Recipient
:
Olle Melander
Funded by:
Novo Nordisk Foundation
Award ID: NNF200C0063465
Award Recipient
:
Olle Melander
Funded by:
Swedish Research Council
Award ID: Dnr 2018-02760
Award Recipient
:
Olle Melander
Funded by:
Swedish Heart and Lung Foundation
Award ID: Dnr 20180278
Award Recipient
:
Olle Melander
Funded by:
Ernhold Lundstrom Research Foundation
Award Recipient
:
Olle Melander
Funded by:
Hulda and E Conrad Mossfelts Foundation
Award Recipient
:
Olle Melander
Funded by:
Albert Pahlsson Foundation
Award Recipient
:
Olle Melander
OM was supported by the Swedish Foundation for Strategic Research (IRC LUDC), Swedish
Research Council (SFO-EXODIAB), AIR Lund (Artificially Intelligent use of Registers
at Lund University) research environment (VR; Grant No. 2019-61406), Lund University
Infrastructure Grants for population-based cohorts and metabolomics platforms (STYR
2019/2046), European Research Council AdG 2019-885003, Novo Nordisk Foundation NNF200C0063465,
Swedish Research Council grant Dnr 2018-02760, Swedish Heart and Lung Foundation grant
Dnr 20180278, Ernhold Lundstrom Research Foundation, Hulda and E Conrad Mossfelts
Foundation and the Albert Pahlsson Foundation. The funders had no role in study design,
data collection and analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Lipids
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Cardiovascular Diseases
Subject:
Medicine and Health Sciences
Subject:
Cardiology
Subject:
Cardiovascular Medicine
Subject:
Cardiovascular Diseases
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Disorders
Subject:
Diabetes Mellitus
Subject:
Type 2 Diabetes
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Metabolic Disorders
Subject:
Diabetes Mellitus
Subject:
Type 2 Diabetes
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Disorders
Subject:
Diabetes Mellitus
Subject:
Type 2 Diabetes
Subject:
Type 2 Diabetes Risk
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Metabolic Disorders
Subject:
Diabetes Mellitus
Subject:
Type 2 Diabetes
Subject:
Type 2 Diabetes Risk
Subject:
Medicine and Health Sciences
Subject:
Epidemiology
Subject:
Medical Risk Factors
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Cardiovascular Diseases
Subject:
Cardiovascular Disease Risk
Subject:
Medicine and Health Sciences
Subject:
Cardiology
Subject:
Cardiovascular Medicine
Subject:
Cardiovascular Diseases
Subject:
Cardiovascular Disease Risk
Subject:
Medicine and Health Sciences
Subject:
Epidemiology
Subject:
Medicine and Health Sciences
Subject:
Epidemiology
Subject:
Medical Risk Factors
Subject:
Cancer Risk Factors
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancer Risk Factors