Hanxiao Sun:
ORCID: https://orcid.org/0000-0003-0083-8471
Role: Formal analysisRole: VisualizationRole: Writing – original draftRole: Writing
– review & editing
Meng Lin:
ORCID: https://orcid.org/0000-0003-4603-0718
Role: Data curationRole: Formal analysisRole: VisualizationRole: Writing – original
draft
Emily M. Russell:
ORCID: https://orcid.org/0000-0001-9151-0310
Role: Formal analysisRole: ValidationRole: Writing – review & editing
Ryan L. Minster:
ORCID: https://orcid.org/0000-0001-7382-6717
Role: Data curationRole: SupervisionRole: Writing – review & editing
Tsz Fung Chan:
ORCID: https://orcid.org/0000-0003-3438-4068
Role: Formal analysisRole: Writing – review & editing
Bryan L. Dinh:
ORCID: https://orcid.org/0000-0002-5351-6145
Role: Data curationRole: Formal analysis
Take Naseri: Role: Data curationRole: Resources
Muagututi‘a Sefuiva Reupena: Role: Data curationRole: Resources
Annette Lum-Jones: Role: ResourcesRole: Writing – review & editing
Iona Cheng:
ORCID: https://orcid.org/0000-0003-4132-2893
Role: ResourcesRole: SupervisionRole: Writing – review & editing
Lynne R. Wilkens: Role: Data curationRole: ResourcesRole: Writing – review & editing
Loïc Le Marchand: Role: SupervisionRole: Writing – review & editing
Christopher A. Haiman: Role: ResourcesRole: SupervisionRole: Writing – review & editing
Charleston W. K. Chiang:
ORCID: https://orcid.org/0000-0002-0668-7865
Role: ConceptualizationRole: InvestigationRole: SupervisionRole: VisualizationRole:
Writing – original draftRole: Writing – review & editing
Joseph Lachance: Role: Editor
Journal ID (nlm-ta): PLoS Genet
Journal ID (iso-abbrev): PLoS Genet
Journal ID (publisher-id): plos
Journal ID (pmc): plosgen
Title:
PLoS Genetics
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7390
ISSN
(Electronic):
1553-7404
Publication date
(Electronic):
11
February
2021
Publication date Collection:
February
2021
Volume: 17
Issue: 2
Electronic Location Identifier: e1009273
Affiliations
[1
]
Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of
Medicine, University of Southern California, Los Angeles, California, United States
of America
[2
]
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh,
Pittsburgh, Pennsylvania, United States of America
[3
]
Department of Quantitative and Computational Biology, University of Southern California,
Los Angeles, California, United States of America
[4
]
Ministry of Health, Government of Samoa, Apia, Samoa
[5
]
Lutia i Puava ae Mapu i Fagalele, Apia, Samoa
[6
]
Epidemiology Program, University of Hawai‘i Cancer Center, University of Hawai‘i,
Manoa, Honolulu, Hawaii, United States of America
[7
]
Department of Epidemiology and Biostatistics, University of California San Francisco,
San Francisco, California, United States of America
Georgia Institute of Technology, UNITED STATES
Author notes
The authors have declared that no competing interests exist.
¶ Membership of Samoan Obesity, Lifestyle, and Genetic Adaptations (OLaGA) Study Group
is provided in the Acknowledgement.
Author information
Article
Publisher ID:
PGENETICS-D-20-00764
DOI: 10.1371/journal.pgen.1009273
PMC ID: 7877570
PubMed ID: 33571193
SO-VID: 28b79218-43a4-42ad-ac1c-f35ac13d6052
Copyright © © 2021 Sun et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
The Multiethnic Cohort was funded through grants from the National Cancer Institute
(U01CA164973, P01CA168530) and National Human Genome Research Institute (U01HG007397).
Whole genome sequencing (WGS) for the Trans-Omics in Precision Medicine (TOPMed) program
was supported by the National Heart, Lung and Blood Institute (NHLBI). NHLBI TOPMed:
Genome-wide Association Study of Adiposity in Samoans was funded by NHLBI (R01HL093093
[S.T. McGarvey] and (R01 HL133040 [R.L.M.]); WGS (phs000972) was performed at the
University of Washington Northwest Genomics Center (HHSN268201100037C) and the New
York Genome Center (HHSN268201500016C). Centralized read mapping and genotype calling,
along with variant quality metrics and filtering were provided by the TOPMed Informatics
Research Center (3R01HL-117626-02S1; contract HHSN268201800002I). Phenotype harmonization,
data management, sample-identity QC, and general study coordination were provided
by the TOPMed Data Coordinating Center (3R01HL-120393-02S1; contract HHSN268201800001I).
This research is also supported by Samoan Ministry of Health and the Samoa Bureau
of Statistics. Computation for this work is supported by the University of Southern
California's Center for Advanced Research Computing (
https://carc.usc.edu). The funders had no role in study design, data collection and analysis, decision
to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
People and Places
Subject:
Population Groupings
Subject:
Ethnicities
Subject:
Austronesian People
Subject:
Polynesian People
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genomics
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Adipose Tissue
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Adipose Tissue
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genetics of Disease
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Obesity
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Cardiovascular Diseases
Subject:
Cardiovascular Disease Risk
Subject:
Medicine and Health Sciences
Subject:
Cardiology
Subject:
Cardiovascular Medicine
Subject:
Cardiovascular Diseases
Subject:
Cardiovascular Disease Risk
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Body Mass Index
Subject:
Medicine and Health Sciences
Subject:
Cardiology
Subject:
Heart Failure