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      ExoCarta: A web-based compendium of exosomal cargo

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          Abstract

          Exosomes are membranous vesicles that are released by a variety of cells into the extracellular microenvironment and are implicated in intercellular communication. As exosomes contain RNA, proteins and lipids, there is a significant interest in characterizing the molecular cargo of exosomes. Here, we describe ExoCarta ( http://www.exocarta.org), a manually curated web-based compendium of exosomal proteins, RNAs and lipids. Since its inception, the database has been highly accessed (>54,000 visitors from 135 countries). The current version of ExoCarta hosts 41,860 proteins, >7,540 RNA and 1,116 lipid molecules from more than 286 exosomal studies annotated with ISEV minimal experimental requirements for definition of extracellular vesicles. Besides, ExoCarta features dynamic protein-protein interaction networks and biological pathways of exosomal proteins. Users can download most often identified exosomal proteins based on the number of studies. The downloaded files can further be imported directly into FunRich ( http://www.funrich.org) tool for additional functional enrichment and interaction network analysis.

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          Author and article information

          Journal
          2985088R
          4967
          J Mol Biol
          J. Mol. Biol.
          Journal of molecular biology
          0022-2836
          1089-8638
          27 October 2015
          03 October 2015
          22 February 2016
          22 February 2017
          : 428
          : 4
          : 688-692
          Affiliations
          [1 ]Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia
          [2 ]Department of Computer Science and Information Technology, La Trobe University, Melbourne, Victoria 3086, Australia
          [3 ]Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne, Victoria 3086, Australia
          Author notes
          [* ]To whom correspondence should be addressed: Dr. Shivakumar Keerthikumar, Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria 3086, Australia, Tel: +61 3 9479 2647; Fax: +61 3 9479 1266, S.Keerthikumar@ 123456latrobe.edu.au , Dr. Suresh Mathivanan, Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Victoria 3086, Australia, Tel: +61 3 9479 2565; Fax: +61 3 9479 1266, S.Mathivanan@ 123456latrobe.edu.au
          Article
          PMC4783248 PMC4783248 4783248 nihpa731220
          10.1016/j.jmb.2015.09.019
          4783248
          26434508
          2ce2ef27-0823-4ba3-9b94-4e3a795f188f
          History
          Categories
          Article

          Extracellular vesicles,Exosomes,FunRich,Protein-protein interactions

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