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      Let’s talk about (biological) sex

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          You spent years investigating your beloved protein. You generated mouse models, found a phenotype and fixed it with a drug. You even used human cells to reveal a conserved mechanism. But a prestigious journal has rejected your manuscript because you did not include females. Here is why you should not be mad at them.

          Abstract

          Irene Miguel-Aliaga comments on the importance of considering biological sex as an experimental variable.

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          Most cited references10

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          Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon.

          Jeffrey Mogil (2012)
          A clear majority of patients with chronic pain are women; however, it has been surprisingly difficult to determine whether this sex bias corresponds to actual sex differences in pain sensitivity. A survey of the currently available epidemiological and laboratory data indicates that the evidence for clinical and experimental sex differences in pain is overwhelming. Various explanations for this phenomenon have been given, ranging from experiential and sociocultural differences in pain experience between men and women to hormonally and genetically driven sex differences in brain neurochemistry.
          Article 0 comments Cited 314 times – based on 0 reviews     Review now
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            Sex and gender analysis improves science and engineering

            Cara Tannenbaum, Robert P. Ellis, Friederike Eyssel … (2019)
            Article 0 comments Cited 134 times – based on 0 reviews     Review now
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              Considering sex as a biological variable will require a global shift in science culture

              Rebecca M. Shansky, Anne Murphy (2021)
              Article 0 comments Cited 124 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Irene Miguel-Aliaga: i.miguel-aliaga@imperial.ac.uk
                Journal
                Journal ID (nlm-ta): Nat Rev Mol Cell Biol
                Journal ID (iso-abbrev): Nat Rev Mol Cell Biol
                Title: Nature Reviews. Molecular Cell Biology
                Publisher: Nature Publishing Group UK (London )
                ISSN (Print): 1471-0072
                ISSN (Electronic): 1471-0080
                Publication date (Electronic): 23 February 2022
                Pages: 1-2
                Affiliations
                [1 ]GRID grid.14105.31, ISNI 0000000122478951, MRC London Institute of Medical Sciences, ; London, UK
                [2 ]GRID grid.7445.2, ISNI 0000 0001 2113 8111, Faculty of Medicine, , Imperial College London, ; London, UK
                Article
                Publisher ID: 467
                DOI: 10.1038/s41580-022-00467-w
                PMC ID: 8865486
                PubMed ID: 35197611
                SO-VID: 2df2cfd1-ee45-4d91-a641-c40108e798d2
                Copyright © © Springer Nature Limited 2022
                License:

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

                History
                Categories
                Subject: Comment

                Keywords: cell biology,physiology,molecular biology,scientific community
                Data availability:
                Keywords: cell biology, physiology, molecular biology, scientific community

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