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      Supercritical fluid extracts of rosemary leaves exhibit potent anti-inflammation and anti-tumor effects.

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          Abstract

          Supercritical fluid SF-CO2 treatment of Rosemarinus officinalis L. fresh leaves under optimum conditions (80 degrees C at 5,000 psi) yielded 5.3% of extract supercritical fluid extraction (SFE)-80, in which five major active principles were identified by liquid chromatography/mass spectrometry (LC/MS), viz., rosmarinic acid, carnosol, 12-methoxycarnosic acid, carnosic acid, and methyl carnosate. Total phenolic content was 155.8 mg/ gallic acid equivalent (GAE)/g in SFE-80, which showed 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging of 81.86% at 0.01 mg/ml. When treated in RAW 264.7, apparent dose-dependent NO inhibition occurred at dosages of 1.56 to 6.25 microg/ml, and more drastically at 12.5 and 25 microg/ml. At 0.5 to 5.0 microg/ml, SFE-80 exhibited dose-dependent viability suppression and significant tumor necrosis factor alpha (TNF-alpha) production in Hep 3B, whereas no effect was found in Chang liver cells. Furthermore, no effect was observed in RAW 264.7 at dosages of 3.13 to 25 microg/ml, indicating that SFE-80 exhibited a noncytotoxic character. Conclusively, rosemary can be considered an herbal anti-inflammatory and anti-tumor agent.

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          Author and article information

          Journal
          Biosci Biotechnol Biochem
          Bioscience, biotechnology, and biochemistry
          Japan Society for Bioscience, Biotechnology, and Agrochemistry
          0916-8451
          0916-8451
          Sep 2007
          : 71
          : 9
          Affiliations
          [1 ] Division of Basic Medical Science, Hungkuang University, No 34, Chung Chie Rd, Shalu County, Taichung Hsien, 43302, Taiwan.
          Article
          JST.JSTAGE/bbb/70199
          10.1271/bbb.70199
          17827696
          3277d155-c837-427c-a1bb-9a6d882bcaa9

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