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A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
August 2011
August 2011
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Abstract
Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes,
and long noncoding RNAs "talk" to each other using microRNA response elements (MREs)
as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA)
activity forms a large-scale regulatory network across the transcriptome, greatly
expanding the functional genetic information in the human genome and playing important
roles in pathological conditions, such as cancer.
Copyright © 2011 Elsevier Inc. All rights reserved.