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      Endothelial Targets in Stroke: Translating Animal Models to Human

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          Abstract

          Cerebral ischemia (stroke) induces injury to the cerebral endothelium that may contribute to parenchymal injury and worsen outcome. This review focuses on current preclinical studies examining how to prevent ischemia-induced endothelial dysfunction. It particularly focuses on targets at the endothelium itself. Those include endothelial tight junctions, transcytosis, endothelial cell death and adhesion molecule expression. It also examines how such studies are being translated to the clinic, especially as adjunct therapies for preventing intracerebral hemorrhage during reperfusion of the ischemic brain. Identification of endothelial targets may prove valuable in a search for combination therapies that would specifically protect different cell types in ischemia.

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          Author and article information

          Journal
          9505803
          8623
          Arterioscler Thromb Vasc Biol
          Arterioscler. Thromb. Vasc. Biol.
          Arteriosclerosis, thrombosis, and vascular biology
          1079-5642
          1524-4636
          28 August 2019
          12 September 2019
          November 2019
          01 November 2020
          : 39
          : 11
          : 2240-2247
          Affiliations
          [1 ]Department of Neurosurgery, University of Michigan
          [2 ]Department of Pathology, University of Michigan
          [3 ]Department of Neurology, University of Michigan
          [4 ]Department of Molecular and Integrative Physiology, University of Michigan
          [5 ]Neurology Service, VA Ann Arbor Healthcare System, Department of Veterans Affairs
          Author notes
          Correspondence: Richard F. Keep, Ph.D., Department of Neurosurgery, University of Michigan, 5018 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, Phone: (734) 764-1207, rkeep@ 123456umich.edu
          Article
          PMC6812626 PMC6812626 6812626 nihpa1538435
          10.1161/ATVBAHA.119.312816
          6812626
          31510792
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