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      Palladiumkatalysierte Kreuzkupplungen: eine historische Perspektive im Kontext der Nobel-Preise 2010

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      Angewandte Chemie

      Wiley-Blackwell

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          Palladium(II)-catalyzed C-H activation/C-C cross-coupling reactions: versatility and practicality.

          In the past decade, palladium-catalyzed C-H activation/C-C bond-forming reactions have emerged as promising new catalytic transformations; however, development in this field is still at an early stage compared to the state of the art in cross-coupling reactions using aryl and alkyl halides. This Review begins with a brief introduction of four extensively investigated modes of catalysis for forming C-C bonds from C-H bonds: Pd(II)/Pd(0), Pd(II)/Pd(IV), Pd(0)/Pd(II)/Pd(IV), and Pd(0)/Pd(II) catalysis. A more detailed discussion is then directed towards the recent development of palladium(II)-catalyzed coupling of C-H bonds with organometallic reagents through a Pd(II)/Pd(0) catalytic cycle. Despite the progress made to date, improving the versatility and practicality of this new reaction remains a tremendous challenge.
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            Palladium(II)-katalysierte C-H-Aktivierung/C-C-Kreuzkupplung: Vielseitigkeit und Anwendbarkeit

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              Towards mild metal-catalyzed C-H bond activation.

              Functionalizing traditionally inert carbon-hydrogen bonds represents a powerful transformation in organic synthesis, providing new entries to valuable structural motifs and improving the overall synthetic efficiency. C-H bond activation, however, often necessitates harsh reaction conditions that result in functional group incompatibilities and limited substrate scope. An understanding of the reaction mechanism and rational design of experimental conditions have led to significant improvement in both selectivity and applicability. This critical review summarizes and discusses endeavours towards the development of mild C-H activation methods and wishes to trigger more research towards this goal. In addition, we examine select examples in complex natural product synthesis to demonstrate the synthetic utility of mild C-H functionalization (84 references). This journal is © The Royal Society of Chemistry 2011
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                Author and article information

                Journal
                Angewandte Chemie
                Angew. Chem.
                Wiley-Blackwell
                00448249
                May 21 2012
                May 21 2012
                : 124
                : 21
                : 5150-5174
                Article
                10.1002/ange.201107017
                © 2012
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