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Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia.
Charles G Mullighan
1 ,
Xiaoping Su ,
Jinghui Zhang ,
Ina Radtke ,
Letha A A Phillips ,
Christopher B Miller ,
Jing Ma ,
Wei Liu ,
Cheng Cheng ,
Brenda A Schulman ,
Richard C Harvey ,
I-Ming Chen ,
Robert J Clifford ,
William L Carroll ,
Gregory Reaman ,
W Paul Bowman ,
Meenakshi Devidas ,
Daniela S Gerhard ,
Wenjian Yang ,
Mary V Relling ,
Sheila A Shurtleff ,
Dario Campana ,
Michael J Borowitz ,
Ching-Hon Pui ,
Malcolm Smith ,
Stephen P Hunger ,
Cheryl L Willman ,
James R Downing
Jan 29 2009
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Abstract
Despite best current therapy, up to 20% of pediatric patients with acute lymphoblastic leukemia (ALL) have a relapse. Recent genomewide analyses have identified a high frequency of DNA copy-number abnormalities in ALL, but the prognostic implications of these abnormalities have not been defined.