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      Temperature-responsive DNA-gated nanocarriers for intracellular controlled release

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          Abstract

          We report a novel strategy to construct temperature-responsive nanocarriers for controlled release based on mesoporous silica and single-stranded DNA valves.

          Abstract

          We report a novel strategy to construct temperature-responsive nanocarriers for controlled release based on mesoporous silica and reversible single-stranded DNA valves.

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          Mesoporous silica nanoparticles in biomedical applications.

          Zongxi Li, Jonathan C Barnes, Aleksandr Bosoy … (2012)
          This tutorial review provides an outlook on nanomaterials that are currently being used for theranostic purposes, with a special focus on mesoporous silica nanoparticle (MSNP) based materials. MSNPs with large surface area and pore volume can serve as efficient carriers for various therapeutic agents. The functionalization of MSNPs with molecular, supramolecular or polymer moieties, provides the material with great versatility while performing drug delivery tasks, which makes the delivery process highly controllable. This emerging area at the interface of chemistry and the life sciences offers a broad palette of opportunities for researchers with interests ranging from sol-gel science, the fabrication of nanomaterials, supramolecular chemistry, controllable drug delivery and targeted theranostics in biology and medicine.
          Article 0 comments Cited 452 times – based on 0 reviews     Review now
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            Functionalized mesoporous silica materials for controlled drug delivery.

            Piaoping Yang, Shili Gai, Jun Lin (2012)
            In the past decade, non-invasive and biocompatible mesoporous silica materials as efficient drug delivery systems have attracted special attention. Great progress in structure control and functionalization (magnetism and luminescence) design has been achieved for biotechnological and biomedical applications. This review highlights the most recent research progress on silica-based controlled drug delivery systems, including: (i) pure mesoporous silica sustained-release systems, (ii) magnetism and/or luminescence functionalized mesoporous silica systems which integrate targeting and tracking abilities of drug molecules, and (iii) stimuli-responsive controlled release systems which are able to respond to environmental changes, such as pH, redox potential, temperature, photoirradiation, and biomolecules. Although encouraging and potential developments have been achieved, design and mass production of novel multifunctional carriers, some practical biological application, such as biodistribution, the acute and chronic toxicities, long-term stability, circulation properties and targeting efficacy in vivo are still challenging. This journal is © The Royal Society of Chemistry 2012
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              Nanomedicine--challenge and perspectives.

              Kristina Riehemann, Stefan Schneider, Thomas Luger … (2009)
              The application of nanotechnology concepts to medicine joins two large cross-disciplinary fields with an unprecedented societal and economical potential arising from the natural combination of specific achievements in the respective fields. The common basis evolves from the molecular-scale properties relevant to the two fields. Local probes and molecular imaging techniques allow surface and interface properties to be characterized on a nanometer scale at predefined locations, while chemical approaches offer the opportunity to elaborate and address surfaces, for example, for targeted drug delivery, enhanced biocompatibility, and neuroprosthetic purposes. However, concerns arise in this cross-disciplinary area about toxicological aspects and ethical implications. This Review gives an overview of selected recent developments and applications of nanomedicine.
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                Author and article information

                Journal
                Journal ID (publisher-id): CHCOFS
                Title: Chem. Commun.
                Abbreviated Title: Chem. Commun.
                Publisher: Royal Society of Chemistry (RSC)
                ISSN (Print): 1359-7345
                ISSN (Electronic): 1364-548X
                Publication date Created: 2014
                Publication date (Electronic): 2014
                Volume: 50
                Issue: 26
                Pages: 3494-3497
                Affiliations
                [1 ]College of Chemistry
                [2 ]Chemical Engineering and Materials Science
                [3 ]Collaborative Innovation Center of Functionalized Probes for Chemical Imaging
                [4 ]Key Laboratory of Molecular and Nano Probes
                [5 ]Ministry of Education
                Article
                DOI: 10.1039/C3CC49183H
                PubMed ID: 24554023
                SO-VID: 56b84890-27cf-4d95-a409-500965ded472
                Copyright © © 2014
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