Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Long noncoding RNAs (lncRNAs) have been proven to play critical roles in diabetic retinopathy (DR). This study investigated whether the single nucleotide polymorphism (SNP) of long intergenic noncoding RNA 00673 ( LINC00673) affects the clinical characteristics of diabetic retinopathy (DR). A total of three loci of LINC00673 SNPs (rs6501551, rs9914618, and rs11655237) were genotyped using TaqMan allelic discrimination in 276 and 454 individuals with and without DR, respectively. Our results revealed that LINC00673 SNP rs11655237 CT genotype (AOR: 1.592, 95% CI: 1.059–2.395, p = 0.026), CT + TT genotype (AOR: 1.255, 95% CI: 1.029–1.531, p = 0.025), and allele T (AOR: 1.185, 95% CI: 1.004–1.397, p = 0.044) yielded higher ratios in the non-proliferative diabetic retinopathy (NPDR) subgroup than in the non-DR group. Furthermore, the interval of diabetes mellitus (DM) was significantly shorter in the LINC00673 SNP rs11655237 CT + TT variant than that in the LINC00673 SNP rs11655237 wild type (10.44 ± 7.10 vs. 12.98 ± 8.34, p = 0.009). In conclusion, the LINC00673 SNP rs11655237 T allele is associated with a higher probability of NPDR development. Patients with the LINC00673 SNP rs11655237 CT + TT variant exhibited a short DM interval.

Related collections

Most cited references 47

Record: found
Abstract: found
Article: not found

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

Sylvia Ley, Yan Zheng, Frank Hu (2017)

Globally, the number of people with diabetes mellitus has quadrupled in the past three decades, and diabetes mellitus is the ninth major cause of death. About 1 in 11 adults worldwide now have diabetes mellitus, 90% of whom have type 2 diabetes mellitus (T2DM). Asia is a major area of the rapidly emerging T2DM global epidemic, with China and India the top two epicentres. Although genetic predisposition partly determines individual susceptibility to T2DM, an unhealthy diet and a sedentary lifestyle are important drivers of the current global epidemic; early developmental factors (such as intrauterine exposures) also have a role in susceptibility to T2DM later in life. Many cases of T2DM could be prevented with lifestyle changes, including maintaining a healthy body weight, consuming a healthy diet, staying physically active, not smoking and drinking alcohol in moderation. Most patients with T2DM have at least one complication, and cardiovascular complications are the leading cause of morbidity and mortality in these patients. This Review provides an updated view of the global epidemiology of T2DM, as well as dietary, lifestyle and other risk factors for T2DM and its complications.

0 comments Cited 1396 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Is Open Access

Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis.

Seth R Flaxman, Rupert Bourne, Serge Resnikoff … (2017)

Contemporary data for causes of vision impairment and blindness form an important basis of recommendations in public health policies. Refreshment of the Global Vision Database with recently published data sources permitted modelling of cause of vision loss data from 1990 to 2015, further disaggregation by cause, and forecasts to 2020.

0 comments Cited 793 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

LncRNA-mediated regulation of cell signaling in cancer

Wan-Xin Peng, Pratirodh Koirala, Yin-Yuan Mo (2017)

To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered through functional genomics studies. Importantly, lncRNAs have been shown, in many cases, to function as master regulators for gene expression and thus, they can play a critical role in various biological functions and disease processes including cancer. Although the lncRNA-mediated gene expression involves various mechanisms, such as regulation of transcription, translation, protein modification, and the formation of RNA-protein or protein-protein complexes, in this review we discuss the latest developments primarily in important cell signaling pathways regulated by lncRNAs in cancer.

0 comments Cited 693 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Chien-Ning Huang: URI : https://loop.frontiersin.org/people/1319325/overview

Min-Yen Hsu: URI : https://loop.frontiersin.org/people/1438141/overview

Shun-Fa Yang: URI : https://loop.frontiersin.org/people/693905/overview

Journal

Journal ID (nlm-ta): Front Genet

Journal ID (iso-abbrev): Front Genet

Journal ID (publisher-id): Front. Genet.

Title: Frontiers in Genetics

Publisher: Frontiers Media S.A.

ISSN (Electronic): 1664-8021

Publication date (Electronic): 25 April 2022

Publication date Collection: 2022

Volume: 13

Electronic Location Identifier: 889530

Affiliations

[1] ¹ Institute of Medicine , Chung Shan Medical University , Taichung, Taiwan

[2] ² Department of Ophthalmology , Changhua Christian Hospital , Changhua, Taiwan

[3] ³ School of Medicine , Chung Shan Medical University , Taichung, Taiwan

[4] ⁴ Department of Internal Medicine , Division of Endocrinology and Metabolism , Chung Shan Medical University Hospital , Taichung, Taiwan

[5] ⁵ Department of Ophthalmology , Chung Shan Medical University Hospital , Taichung, Taiwan

[6] ⁶ Department of Ophthalmology , Nobel Eye Institute , Taipei, Taiwan

[7] ⁷ Department of Medical Research , Chung Shan Medical University Hospital , Taichung, Taiwan

Author notes

Edited by: Yen-Wei Chu, National Chung Hsing University, Taiwan

Reviewed by: Leyi Wei, Shandong University, China

Xing-Hua Liao, Wuhan University of Science and Technology, China

*Correspondence: Shun-Fa Yang, ysf@ 123456csmu.edu.tw

This article was submitted to Computational Genomics, a section of the journal Frontiers in Genetics

Article

Publisher ID: 889530

DOI: 10.3389/fgene.2022.889530

PMC ID: 9081725

PubMed ID: 35547254

SO-VID: 60728e4e-3dda-4d9a-899f-5b77aff145fd

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

History

Date received : 04 March 2022

Date accepted : 24 March 2022

Comments

Comment on this article

scite_

Cited by 1

Association of SDF-1 and its receptor CXCR4 polymorphisms on the susceptibility of diabetic retinopathy in the Taiwanese population
Authors: Shu-Yen Peng, Chih-Chun Chuang, Yih-Shiou Hwang …

See all cited by

Most referenced authors 616

See all reference authors

Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy

Read this article at

Abstract

Related collections

RNA drug delivery

Most cited references 47

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis.

LncRNA-mediated regulation of cell signaling in cancer

Author and article information

Contributors

Journal

Affiliations

Author notes

Article

History

Categories

Comments

Comment on this article

Similar content 373

Cited by 1

Most referenced authors 616