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      Peroxidase-mimicking evodiamine/indocyanine green nanoliposomes for multimodal imaging-guided theranostics for oral squamous cell carcinoma

      research-article
      Author(s): a , c , e , 1 , a , e , 1 , g , a , e , a , e , f , d , a , e , a , e , a , e , b , e , ∗∗ , a , e , ∗
      Publication date (Electronic):
      Journal: Bioactive Materials
      Publisher: KeAi Publishing
      Keywords: Oral squamous cell carcinoma, Evodiamine, Peroxidase-mimicking, Trimodal antitumor therapy, EVO, evodiamine, ICG, indocyanine green, OSCC, Oral squamous cell carcinoma, PET/CT, positron emission tomography/computed tomography, ROS, reactive oxygen species, NIR, Near-infrared, PDT, Photodynamic therapy, CDT, Chemodynamic therapy, FDA, Food and Drug Administration, EPR, enhanced permeability and retention, DI water, deionized water, TEM, transmission electron microscope, DLS, dynamic light scattering, THF, tetrahydrofuran, SOSG, singlet oxygen sensor green, CAT, Catalase Activity, TMB, tetramethylbenzidine, ATCC, American Type Culture Collection, DMEM, Dulbecco's modified Eagle's medium, SD, Sprague-Dawley, PBS, polarization beam splitter, FBS, fetal bovine serum, HRP, horseradish peroxidase, FI, fluorescence imaging

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          Abstract

          Here, evodiamine (EVO) and the photosensitizer indocyanine green (ICG) were integrated into a liposomal nanoplatform for noninvasive diagnostic imaging and combinatorial therapy against oral squamous cell carcinoma (OSCC). EVO, as an active component extracted from traditional Chinese medicine, not only functioned as an antitumor chemotherapeutic agent but was also capable of 68Ga-chelation, thus working as a contrast agent for positron emission tomography/computed tomography (PET/CT) imaging. Moreover, EVO could exhibit peroxidase-like catalytic activity, converting endogenous tumor H 2O 2 into cytotoxic reactive oxygen species (ROS), enabling Chemo catalytic therapy beyond the well-known chemotherapy effect of EVO. As proven by in vitro and in vivo experiments, guided by optical imaging and PET/CT imaging, we show that the theragnostic liposomes have a significant inhibiting effect on in situ tongue tumor through photodynamic therapy combined with chemodynamic chemotherapy.

          Graphical abstract

          Highlights

          • •

            Proposing water-soluble nanoliposomes to solve the problem of drug insoluble in water.

          • •

            Evodiamine is found to have HRP mimic catalase activity.

          • •

            EI@lipo displays photodynamic/chemodynamic/chemo therapy abilities.

          • •

            Ei@Lipo significantly inhibits tongue tumor through in situ.

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          Most cited references46

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          Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

          Ahmedin Jemal, Lindsey A Torre, Rebecca Siegel … (2018)
          This article provides a status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across 20 world regions. There will be an estimated 18.1 million new cancer cases (17.0 million excluding nonmelanoma skin cancer) and 9.6 million cancer deaths (9.5 million excluding nonmelanoma skin cancer) in 2018. In both sexes combined, lung cancer is the most commonly diagnosed cancer (11.6% of the total cases) and the leading cause of cancer death (18.4% of the total cancer deaths), closely followed by female breast cancer (11.6%), prostate cancer (7.1%), and colorectal cancer (6.1%) for incidence and colorectal cancer (9.2%), stomach cancer (8.2%), and liver cancer (8.2%) for mortality. Lung cancer is the most frequent cancer and the leading cause of cancer death among males, followed by prostate and colorectal cancer (for incidence) and liver and stomach cancer (for mortality). Among females, breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death, followed by colorectal and lung cancer (for incidence), and vice versa (for mortality); cervical cancer ranks fourth for both incidence and mortality. The most frequently diagnosed cancer and the leading cause of cancer death, however, substantially vary across countries and within each country depending on the degree of economic development and associated social and life style factors. It is noteworthy that high-quality cancer registry data, the basis for planning and implementing evidence-based cancer control programs, are not available in most low- and middle-income countries. The Global Initiative for Cancer Registry Development is an international partnership that supports better estimation, as well as the collection and use of local data, to prioritize and evaluate national cancer control efforts. CA: A Cancer Journal for Clinicians 2018;0:1-31. © 2018 American Cancer Society.
          Article 0 comments Cited 26866 times – based on 0 reviews     Review now
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            Chemodynamic Therapy: Tumour Microenvironment-Mediated Fenton and Fenton-like Reactions

            Zhongmin Tang, Yanyan Liu, Mingyuan He … (2019)
            Tailored to the specific tumour microenvironment, which involves acidity and the overproduction of hydrogen peroxide, advanced nanotechnology has been introduced to generate the hydroxyl radical (. OH) primarily for tumour chemodynamic therapy (CDT) through the Fenton and Fenton-like reactions. Numerous studies have investigated the enhancement of CDT efficiency, primarily the increase in the amount of . OH generated. Notably, various strategies based on the Fenton reaction have been employed to enhance . OH generation, including nanomaterials selection, modulation of the reaction environment, and external energy fields stimulation, which are discussed systematically in this Minireview. Furthermore, the potential challenges and the methods used to facilitate CDT effectiveness are also presented to support this cutting-edge research area.
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              Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2 -Based Nanoagent to Enhance Chemodynamic Therapy

              Zhen Yang, Wei Tang, Gang Niu … (2018)
              Chemodynamic therapy (CDT) utilizes iron-initiated Fenton chemistry to destroy tumor cells by converting endogenous H2 O2 into the highly toxic hydroxyl radical (. OH). There is a paucity of Fenton-like metal-based CDT agents. Intracellular glutathione (GSH) with . OH scavenging ability greatly reduces CDT efficacy. A self-reinforcing CDT nanoagent based on MnO2 is reported that has both Fenton-like Mn2+ delivery and GSH depletion properties. In the presence of HCO3- , which is abundant in the physiological medium, Mn2+ exerts Fenton-like activity to generate . OH from H2 O2 . Upon uptake of MnO2 -coated mesoporous silica nanoparticles (MS@MnO2 NPs) by cancer cells, the MnO2 shell undergoes a redox reaction with GSH to form glutathione disulfide and Mn2+ , resulting in GSH depletion-enhanced CDT. This, together with the GSH-activated MRI contrast effect and dissociation of MnO2 , allows MS@MnO2 NPs to achieve MRI-monitored chemo-chemodynamic combination therapy.
              Article 0 comments Cited 429 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Yu Cai
                Wei Han
                Journal
                Journal ID (nlm-ta): Bioact Mater
                Journal ID (iso-abbrev): Bioact Mater
                Title: Bioactive Materials
                Publisher: KeAi Publishing
                ISSN (Electronic): 2452-199X
                Publication date PMC-release: 13 January 2021
                Publication date Collection: July 2021
                Publication date (Electronic): 13 January 2021
                Volume: 6
                Issue: 7
                Pages: 2144-2157
                Affiliations
                [a ]Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, China
                [b ]Clinical Research Institute, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, 310014, Zhejiang Province, China
                [c ]Pediatric Dentistry, Nanjing Stomatology Hospital, Medical School of Nanjing University, No 30 Zhongyang Road, Nanjing, 210008, China
                [d ]Department of Orthodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, No 30 Zhongyang Road, Nanjing, 210008, China
                [e ]Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, 210008, Nanjing, China
                [f ]Department of Oral Pathology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China
                [g ]Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR, China
                Author notes
                [∗ ]Corresponding author. Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, 30 Zhongyang Road, Nanjing, Jiangsu Province, 210008, China. doctorhanwei@ 123456hotmail.com
                [∗∗ ]Corresponding author. Clinical Research Institute, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, No. 158 Shangtang Road, Hangzhou, Zhejiang Province, 310014, China. iamycai@ 123456163.com
                [1]

                These authors contributed equally.

                Article
                Publisher Item ID: S2452-199X(20)30342-X
                DOI: 10.1016/j.bioactmat.2020.12.016
                PMC ID: 7810628
                PubMed ID: 33511313
                SO-VID: 68ca6569-ac90-46d2-9ada-af03f6616849
                Copyright © © 2021 [The Author/The Authors]
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 23 September 2020
                Date revision received : 28 November 2020
                Date accepted : 20 December 2020
                Categories
                Subject: Article

                Keywords: oral squamous cell carcinoma,evodiamine,peroxidase-mimicking,trimodal antitumor therapy,evo, evodiamine,icg, indocyanine green,oscc, oral squamous cell carcinoma,pet/ct, positron emission tomography/computed tomography,ros, reactive oxygen species,nir, near-infrared,pdt, photodynamic therapy,cdt, chemodynamic therapy,fda, food and drug administration,epr, enhanced permeability and retention,di water, deionized water,tem, transmission electron microscope,dls, dynamic light scattering,thf, tetrahydrofuran,sosg, singlet oxygen sensor green,cat, catalase activity,tmb, tetramethylbenzidine,atcc, american type culture collection,dmem, dulbecco's modified eagle's medium,sd, sprague-dawley,pbs, polarization beam splitter,fbs, fetal bovine serum,hrp, horseradish peroxidase,fi, fluorescence imaging
                Data availability:
                Keywords: oral squamous cell carcinoma, evodiamine, peroxidase-mimicking, trimodal antitumor therapy, evo, evodiamine, icg, indocyanine green, oscc, oral squamous cell carcinoma, pet/ct, positron emission tomography/computed tomography, ros, reactive oxygen species, nir, near-infrared, pdt, photodynamic therapy, cdt, chemodynamic therapy, fda, food and drug administration, epr, enhanced permeability and retention, di water, deionized water, tem, transmission electron microscope, dls, dynamic light scattering, thf, tetrahydrofuran, sosg, singlet oxygen sensor green, cat, catalase activity, tmb, tetramethylbenzidine, atcc, american type culture collection, dmem, dulbecco's modified eagle's medium, sd, sprague-dawley, pbs, polarization beam splitter, fbs, fetal bovine serum, hrp, horseradish peroxidase, fi, fluorescence imaging

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