Effect of VKORC1, CYP2C9, CFP4F2, and GGCX Gene Polymorphisms on Warfarin Dose in Japanese Pediatric Patients.

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Abstract

Warfarin dosage requirements show considerable inter-individual variability. There are some reports of warfarin dose regimens correlating with single nucleotide polymorphisms (SNP) for CYP2C9, VKORC1 and other genes in adults. In children, however, reports are scarcer than in adults and the number of genes examined is more limited. We explored the effects of genetic variation on warfarin dose requirement in Japanese pediatric patients.

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Journal

Journal ID (iso-abbrev): Mol Diagn Ther

Title: Molecular diagnosis & therapy

Publisher: Springer Nature America, Inc

ISSN (Electronic): 1179-2000

ISSN (Print): 1177-1062

Publication date (Electronic): August 2016

Volume: 20

Issue: 4

Affiliations

[1 ] Department of Pediatrics, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.

[2 ] Department of Pediatrics, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan. myanagimachi.ped@tmd.ac.jp.

Article

Publisher Item ID: 10.1007/s40291-016-0212-5

DOI: 10.1007/s40291-016-0212-5

PubMed ID: 27262824

SO-VID: 76b4754a-2b1b-4736-abff-83d9c2263bae

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