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      Health-related quality of life in Indonesian type 2 diabetes mellitus outpatients measured with the Bahasa version of EQ-5D

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          Abstract

          Objectives

          To present EuroQol-5D (EQ-5D) index scores in Indonesian type 2 diabetes mellitus (T2DM) outpatients and to investigate the associations between EQ-5D and socio-demographic characteristics and clinical condition.

          Methods

          Socio-demographic data were collected by interviewing participants, clinical data were obtained from treating physicians and self-reporting. Participants originated from primary and secondary care facilities in the Java and Sulawesi regions. Ordinal regression analysis was conducted with the quintiles of the EQ-5D index scores as the dependent variable to investigate the multivariate association with the participants’ socio-demographic characteristics and clinical condition.

          Results

          907 participants completed the five-level Indonesian version of the EQ-5D. The mean age of the participants was 59.3 (SD 9.7), and 57% were female. The overall EQ-5D index score was 0.77 (0.75–0.79). Male participants had a higher EQ-5D index score compared to females, and the highest percentage of self-reported health problems was in the pain/discomfort dimension (61%). Factors identified as being significantly associated with lower EQ-5D index scores were: (i) treatment in secondary care, (ii) lower educational level, (iii) dependency on caregivers, (iv) not undergoing T2DM therapy, and (v) being a housewife.

          Conclusion

          This study provides estimates of EQ-5D index scores that can be used in health economic evaluations. As housewives were found to experience more T2DM-related pain/discomfort and anxiety/depression, targeted approaches to reduce these problems should be aimed specifically at this group of patients. Potential approaches could involve disease-specific-counselors (health literacy partners) who provide routine monitoring of T2DM therapy as well as improved health promotion among T2DM communities.

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          Most cited references13

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          Multiple Imputation after 18+ Years

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            Assessing proportionality in the proportional odds model for ordinal logistic regression.

            R. Brant (1990)
            The proportional odds model for ordinal logistic regression provides a useful extension of the binary logistic model to situations where the response variable takes on values in a set of ordered categories. The model may be represented by a series of logistic regressions for dependent binary variables, with common regression parameters reflecting the proportional odds assumption. Key to the valid application of the model is the assessment of the proportionality assumption. An approach is described arising from comparisons of the separate (correlated) fits to the binary logistic models underlying the overall model. Based on asymptotic distributional results, formal goodness-of-fit measures are constructed to supplement informal comparisons of the different fits. A number of proposals, including application of bootstrap simulation, are discussed and illustrated with a data example.
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              Quality of life and diabetes

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                Author and article information

                Contributors
                +31 50 363 2442 , +6289636364566 , bustanul.arifin.ury@gmail.com , ury.bustanul.arifin@gmail.com , b.arifin@rug.nl
                Journal
                Qual Life Res
                Qual Life Res
                Quality of Life Research
                Springer International Publishing (Cham )
                0962-9343
                1573-2649
                16 January 2019
                16 January 2019
                2019
                : 28
                : 5
                : 1179-1190
                Affiliations
                [1 ]ISNI 0000 0004 0407 1981, GRID grid.4830.f, Unit of Pharmacotherapy, Epidemiology & Economics (PTE2), Department of Pharmacy, Faculty of Science and Engineering (FSE), , University of Groningen, ; Groningen, The Netherlands
                [2 ]Banggai Laut Public Hospital, Banggai Laut Local Government, Central Sulawesi, Indonesia
                [3 ]ISNI 0000 0004 0407 1981, GRID grid.4830.f, Institute of Science in Healthy Ageing & healthcaRE (SHARE), University Medical Center Groningen (UMCG), , University of Groningen, ; Groningen, The Netherlands
                [4 ]ISNI 0000 0000 9558 4598, GRID grid.4494.d, Department of Health Sciences, University of Groningen, , University Medical Center Groningen, ; Groningen, The Netherlands
                [5 ]ISNI 0000 0000 9558 4598, GRID grid.4494.d, Department of Epidemiology, University of Groningen, , University Medical Center Groningen, ; Groningen, The Netherlands
                [6 ]GRID grid.8570.a, Department of Pharmacology and Therapy, Faculty of Medicine, Public Health and Nursing, , Universitas Gadjah Mada, ; Yogyakarta, Indonesia
                [7 ]Bekasi General Hospital, West Java Local Government, Bekasi, Indonesia
                [8 ]ISNI 000000040459992X, GRID grid.5645.2, Department of Psychiatry, Medical Psychology and Psychotherapy Section, , Erasmus MC University Medical Center, ; Rotterdam, The Netherlands
                [9 ]ISNI 0000 0004 1796 1481, GRID grid.11553.33, Department of Developmental Psychology, Faculty of Psychology, , Padjadjaran University, ; Jatinangor, Indonesia
                [10 ]Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, Indonesia
                [11 ]ISNI 0000 0004 0407 1981, GRID grid.4830.f, Departement of Economics, Econometrics & Finance, Faculty of Economics & Business, , University of Groningen, ; Groningen, Netherlands
                [12 ]GRID grid.440745.6, Department of Pharmacology and Therapy, Faculty of Medicine, , Universitas Airlangga, ; Surabaya, Indonesia
                Author information
                http://orcid.org/0000-0002-2303-310X
                Article
                2105
                10.1007/s11136-019-02105-z
                6470109
                30649698
                7b051e45-2e08-41e9-a781-c70ab539a1e3
                © The Author(s) 2019

                OpenAccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

                History
                : 9 January 2019
                Funding
                Funded by: Beasiswa Pendidikan Indonesia (BPI)/LPDP (the Indonesian Endowment Fund for Education, Ministry of Finance of Republic of Indonesia)
                Award ID: 20130821080334
                Award Recipient :
                Funded by: FundRef http://dx.doi.org/10.13039/501100001721, Rijksuniversiteit Groningen;
                Award ID: Project Code 134502
                Award Recipient :
                Categories
                Article
                Custom metadata
                © Springer Nature Switzerland AG 2019

                Public health
                eq-5d-5l,index scores,type 2 diabetes mellitus,health-related quality of life,indonesia

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