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Cosmetic applications for solid lipid nanoparticles (SLN)
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Abstract
Solid lipid nanoparticles (SLN) are novel delivery systems for pharmaceutical and
cosmetic active ingredients. This paper highlights advantages of SLN for cosmetic
applications. The dependence of the occlusive effect on the particle size of SLN due
to film formation is presented by in vitro data. An in vivo study showed that addition
of 4% SLN to a conventional o/w cream lead to an increase of skin hydration of 31%
after 4 weeks. The application of SLN as physical sunscreens and as active carriers
for molecular sunscreens has also been investigated. The amount of molecular sunscreen
could be decreased by 50% while maintaining the protection level compared to a conventional
emulsion.
Copyright 2002 Elsevier Science B.V.