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MicroRNAs: Target Recognition and Regulatory Functions
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Abstract
MicroRNAs (miRNAs) are endogenous approximately 23 nt RNAs that play important gene-regulatory
roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct
their posttranscriptional repression. This review outlines the current understanding
of miRNA target recognition in animals and discusses the widespread impact of miRNAs
on both the expression and evolution of protein-coding genes.