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AngiomiRs—Key regulators of angiogenesis
June 2009
June 2009
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Abstract
The formation of new blood vessels through the process of angiogenesis is critical
in vascular development and homeostasis. Aberrant angiogenesis leads to a variety
of diseases, such as ischemia and cancer. Recent studies have revealed important roles
for miRNAs in regulating endothelial cell (EC) function, especially angiogenesis.
Mice with EC-specific deletion of Dicer, a key enzyme for generating miRNAs, display
defective postnatal angiogenesis. Specific miRNAs (angiomiRs) have recently been shown
to regulate angiogenesis in vivo. miRNA-126, an EC-restricted miRNA, regulates vascular
integrity and developmental angiogenesis. miR-378, miR-296, and the miR-17-92 cluster
contribute to tumor angiogenesis. Manipulating angiomiRs in the settings of pathological
vascularization represents a new therapeutic approach.