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      Peroxiporins in Cancer

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          Abstract

          The transport of H 2O 2 across membranes by specific aquaporins (AQPs) has been considered the last milestone in the timeline of hydrogen peroxide discoveries in biochemistry. According to its concentration and localization, H 2O 2 can be dangerous or acts as a signaling molecule in various cellular processes as either a paracrine (intercellular) and/or an autocrine (intracellular) signal. In this review, we investigate and critically examine the available information on AQP isoforms able to facilitate H 2O 2 across biological membranes (“peroxiporins”), focusing in particular on their role in cancer. Moreover, the ability of natural compounds to modulate expression and/or activity of peroxiporins is schematically reported and discussed.

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          Cancer chemoprevention with dietary phytochemicals.

          Young-Joon Surh (2003)
          Chemoprevention refers to the use of agents to inhibit, reverse or retard tumorigenesis. Numerous phytochemicals derived from edible plants have been reported to interfere with a specific stage of the carcinogenic process. Many mechanisms have been shown to account for the anticarcinogenic actions of dietary constituents, but attention has recently been focused on intracellular-signalling cascades as common molecular targets for various chemopreventive phytochemicals.
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            Hydroperoxide metabolism in mammalian organs.

            B. Chance, H Sies, A Boveris (1979)
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              Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes.

              Gerd Bienert, Anders L B Møller, Kim A Kristiansen … (2007)
              The metabolism of aerobic organisms continuously produces reactive oxygen species. Although potentially toxic, these compounds also function in signaling. One important feature of signaling compounds is their ability to move between different compartments, e.g. to cross membranes. Here we present evidence that aquaporins can channel hydrogen peroxide (H2O2). Twenty-four aquaporins from plants and mammals were screened in five yeast strains differing in sensitivity toward oxidative stress. Expression of human AQP8 and plant Arabidopsis TIP1;1 and TIP1;2 in yeast decreased growth and survival in the presence of H2O2. Further evidence for aquaporin-mediated H2O2 diffusion was obtained by a fluorescence assay with intact yeast cells using an intracellular reactive oxygen species-sensitive fluorescent dye. Application of silver ions (Ag+), which block aquaporin-mediated water diffusion in a fast kinetics swelling assay, also reversed both the aquaporin-dependent growth repression and the H2O2-induced fluorescence. Our results present the first molecular genetic evidence for the diffusion of H2O2 through specific members of the aquaporin family.
              Article 0 comments Cited 378 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Int J Mol Sci
                Journal ID (iso-abbrev): Int J Mol Sci
                Journal ID (publisher-id): ijms
                Title: International Journal of Molecular Sciences
                Publisher: MDPI
                ISSN (Electronic): 1422-0067
                Publication date (Electronic): 19 March 2019
                Publication date Collection: March 2019
                Volume: 20
                Issue: 6
                Electronic Location Identifier: 1371
                Affiliations
                [1 ]Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy; cecilia.prata@ 123456unibo.it
                [2 ]Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, Corso D’Augusto 237, 47921 Rimini, Italy; silvana.hrelia@ 123456unibo.it
                Author notes
                Author information
                https://orcid.org/0000-0001-7857-4512
                https://orcid.org/0000-0003-3537-4662
                Article
                Publisher ID: ijms-20-01371
                DOI: 10.3390/ijms20061371
                PMC ID: 6471688
                PubMed ID: 30893772
                SO-VID: 8b922f7b-70f3-4151-aaca-6f7a6f63a532
                Copyright © © 2019 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 27 February 2019
                Date accepted : 15 March 2019
                Categories
                Subject: Review

                ScienceOpen disciplines: Molecular biology
                Keywords: aquaporins,peroxiporins,hydrogen peroxide,redox signaling,cancer,phytochemicals
                Data availability:
                ScienceOpen disciplines: Molecular biology
                Keywords: aquaporins, peroxiporins, hydrogen peroxide, redox signaling, cancer, phytochemicals

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