CD146, from a melanoma cell adhesion molecule to a signaling receptor

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Abstract

CD146 was originally identified as a melanoma cell adhesion molecule (MCAM) and highly expressed in many tumors and endothelial cells. However, the evidence that CD146 acts as an adhesion molecule to mediate a homophilic adhesion through the direct interactions between CD146 and itself is still lacking. Recent evidence revealed that CD146 is not merely an adhesion molecule, but also a cellular surface receptor of miscellaneous ligands, including some growth factors and extracellular matrixes. Through the bidirectional interactions with its ligands, CD146 is actively involved in numerous physiological and pathological processes of cells. Overexpression of CD146 can be observed in most of malignancies and is implicated in nearly every step of the development and progression of cancers, especially vascular and lymphatic metastasis. Thus, immunotherapy against CD146 would provide a promising strategy to inhibit metastasis, which accounts for the majority of cancer-associated deaths. Therefore, to deepen the understanding of CD146, we review the reports describing the newly identified ligands of CD146 and discuss the implications of these findings in establishing novel strategies for cancer therapy.

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Author and article information

Contributors

Zhaoqing Wang: clairezqwang@hotmail.com

Xiyun Yan: yanxy@ibp.ac.cn

Journal

Journal ID (nlm-ta): Signal Transduct Target Ther

Journal ID (iso-abbrev): Signal Transduct Target Ther

Title: Signal Transduction and Targeted Therapy

Publisher: Nature Publishing Group UK (London )

ISSN (Print): 2095-9907

ISSN (Electronic): 2059-3635

Publication date (Electronic): 11 August 2020

Publication date PMC-release: 11 August 2020

Publication date Collection: 2020

Volume: 5

Electronic Location Identifier: 148

Affiliations

[1 ]GRID grid.9227.e, ISNI 0000000119573309, Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, , Chinese Academy of Sciences, ; 100101 Beijing, China

[2 ]GRID grid.410726.6, ISNI 0000 0004 1797 8419, College of Life Science, , University of Chinese Academy of Sciences, ; 100049 Beijing, China

[3 ]GRID grid.24696.3f, ISNI 0000 0004 0369 153X, Department of Gastrointestinal Hepatobiliary Tumor Surgery, Beijing Shijitan Hospital, , Capital Medical University, ; 100038 Beijing, China

[4 ]GRID grid.24696.3f, ISNI 0000 0004 0369 153X, Departments of Pathology, Beijing Shijitan Hospital, , Capital Medical University, ; 100038 Beijing, China

[5 ]GRID grid.207374.5, ISNI 0000 0001 2189 3846, Nanozyme Medical Center, School of Basic Medical Sciences, , Zhengzhou University, ; Zhengzhou, 450001 China

Article

Publisher ID: 259

DOI: 10.1038/s41392-020-00259-8

PMC ID: 7421905

PubMed ID: 32782280

SO-VID: 913a4154-6304-40b7-81da-a2a5132ab3b1

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 21 March 2020

Date revision received : 14 June 2020

Date accepted : 18 June 2020

Funding

Funded by: FundRef https://doi.org/10.13039/501100002855, Ministry of Science and Technology of the People’s Republic of China (Chinese Ministry of Science and Technology);

Award ID: 2018ZX10101004002004

Award Recipient : Xiyun Yan

Funded by: FundRef https://doi.org/10.13039/501100004826, Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation);

Award ID: 7192123

Award Recipient : Xiyun Yan

Funded by: The first grant is the National Key Technology Research and Development Program of the Ministry of Science and Technology of China(No.2018ZX10101004002004)