Mersaquinone, A New Tetracene Derivative from the Marine-Derived  Streptomyces  sp. EG1 Exhibiting Activity against Methicillin-Resistant  Staphylococcus aureus  (MRSA)

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

New antibiotics are desperately needed to overcome the societal challenges being encountered with methicillin-resistant Staphylococcus aureus (MRSA). In this study, a new tetracene derivative, named Mersaquinone ( 1), and the known Tetracenomycin D ( 2), Resistoflavin ( 3) and Resistomycin ( 4) have been isolated from the organic extract of the marine Streptomyces sp. EG1. The strain was isolated from a sediment sample collected from the North Coast of the Mediterranean Sea of Egypt. The chemical structure of Mersaquinone ( 1) was assigned based upon data from a diversity of spectroscopic techniques including HRESIMS, IR, 1D and 2D NMR measurements. Mersaquinone ( 1) showed antibacterial activity against methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 3.36 μg/mL.

Related collections

Most cited references 27

Record: found
Abstract: found
Article: found

Is Open Access

The Biodiversity of the Mediterranean Sea: Estimates, Patterns, and Threats

Marta Coll, Chiara Piroddi, Jeroen Steenbeek … (2010)

The Mediterranean Sea is a marine biodiversity hot spot. Here we combined an extensive literature analysis with expert opinions to update publicly available estimates of major taxa in this marine ecosystem and to revise and update several species lists. We also assessed overall spatial and temporal patterns of species diversity and identified major changes and threats. Our results listed approximately 17,000 marine species occurring in the Mediterranean Sea. However, our estimates of marine diversity are still incomplete as yet—undescribed species will be added in the future. Diversity for microbes is substantially underestimated, and the deep-sea areas and portions of the southern and eastern region are still poorly known. In addition, the invasion of alien species is a crucial factor that will continue to change the biodiversity of the Mediterranean, mainly in its eastern basin that can spread rapidly northwards and westwards due to the warming of the Mediterranean Sea. Spatial patterns showed a general decrease in biodiversity from northwestern to southeastern regions following a gradient of production, with some exceptions and caution due to gaps in our knowledge of the biota along the southern and eastern rims. Biodiversity was also generally higher in coastal areas and continental shelves, and decreases with depth. Temporal trends indicated that overexploitation and habitat loss have been the main human drivers of historical changes in biodiversity. At present, habitat loss and degradation, followed by fishing impacts, pollution, climate change, eutrophication, and the establishment of alien species are the most important threats and affect the greatest number of taxonomic groups. All these impacts are expected to grow in importance in the future, especially climate change and habitat degradation. The spatial identification of hot spots highlighted the ecological importance of most of the western Mediterranean shelves (and in particular, the Strait of Gibraltar and the adjacent Alboran Sea), western African coast, the Adriatic, and the Aegean Sea, which show high concentrations of endangered, threatened, or vulnerable species. The Levantine Basin, severely impacted by the invasion of species, is endangered as well. This abstract has been translated to other languages (File S1).

0 comments Cited 420 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Methicillin-resistant Staphylococcus aureus

Andreas Peschel, Surbhi Malhotra-Kumar, Jan Kluytmans … (2018)

Since the 1960s, methicillin-resistant Staphylococcus aureus (MRSA) has emerged, disseminated globally and become a leading cause of bacterial infections in both health-care and community settings. However, there is marked geographical variation in MRSA burden owing to several factors, including differences in local infection control practices and pathogen-specific characteristics of the circulating clones. Different MRSA clones have resulted from the independent acquisition of staphylococcal cassette chromosome mec (SCCmec), which contains genes encoding proteins that render the bacterium resistant to most β-lactam antibiotics (such as methicillin), by several S. aureus clones. The success of MRSA is a consequence of the extensive arsenal of virulence factors produced by S. aureus combined with β-lactam resistance and, for most clones, resistance to other antibiotic classes. Clinical manifestations of MRSA range from asymptomatic colonization of the nasal mucosa to mild skin and soft tissue infections to fulminant invasive disease with high mortality. Although treatment options for MRSA are limited, several new antimicrobials are under development. An understanding of colonization dynamics, routes of transmission, risk factors for progression to infection and conditions that promote the emergence of resistance will enable optimization of strategies to effectively control MRSA. Vaccine candidates are also under development and could become an effective prevention measure.

0 comments Cited 374 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

Ecology of actinomycetes.

M Goodfellow, S. Williams (1982)

0 comments Cited 174 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (nlm-ta): Antibiotics (Basel)

Journal ID (iso-abbrev): Antibiotics (Basel)

Journal ID (publisher-id): antibiotics

Title: Antibiotics

Publisher: MDPI

ISSN (Electronic): 2079-6382

Publication date (Electronic): 14 May 2020

Publication date Collection: May 2020

Volume: 9

Issue: 5

Electronic Location Identifier: 252

Affiliations

[1 ]Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA; mck008@ 123456ucsd.edu (M.C.K.); rcullum@ 123456ucsd.edu (R.C.); nehad.mo.salah@ 123456std.pharma.cu.edu.eg (N.M.S.)

[2 ]Natural Products Research Unit, Chemistry Department, Faculty of Science, Helwan University, Cairo 11795, Egypt; ashebishy@ 123456gmail.com (A.M.S.H.); Halaasklany89@ 123456gmail.com (H.A.M.)

[3 ]Botany and Microbiology Department, Faculty of Science, Helwan University, Cairo 11795, Egypt; professor.ahmed85@ 123456googlemail.com

Author notes

[* ]Correspondence: mabdelfattah@ 123456science.helwan.edu.eg (M.S.A.); wfenical@ 123456ucsd.edu (W.F.); Tel.: +2-114-647-5234 (M.S.A.); +1-858-534-2133 (W.F.)

Author information

Min Cheol Kim https://orcid.org/0000-0002-9861-6131

Reiko Cullum https://orcid.org/0000-0003-0884-1640

Ahmed H. I. Faraag https://orcid.org/0000-0002-2568-6059

Mohamed S. Abdelfattah https://orcid.org/0000-0002-6416-9011

Article

Publisher ID: antibiotics-09-00252

DOI: 10.3390/antibiotics9050252

PMC ID: 7277363

PubMed ID: 32422934

SO-VID: 97b5a7fe-0f30-49f8-a518-90f47de9ac07

License:

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

Mersaquinone, A New Tetracene Derivative from the Marine-Derived Streptomyces sp. EG1 Exhibiting Activity against Methicillin-Resistant Staphylococcus aureus (MRSA)

Read this article at

Abstract

Related collections

Fandom activity

Most cited references 27

The Biodiversity of the Mediterranean Sea: Estimates, Patterns, and Threats

Methicillin-resistant Staphylococcus aureus

Ecology of actinomycetes.

Author and article information

Journal

Affiliations

Author notes

Author information

Article

History

Categories

Comments

Comment on this article

Similar content 231

Cited by 5

Most referenced authors 398