Erratum: The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas

Abstract

Erratum During the typesetting of the final version of the article [1] some data in Table 1 have been accidentally changed. These data were correct in the provisional version of the article. A correct Table 1 is as follows: Table 1 List of the non-clonal mutations identified in the BCR-ABL1 fusion gene from imatinib-resistant K562 clones Samples Position AA change Codon change Sequence context Control 1409 E495G GAA > GGA 1472 R491Q CGG > CAG GCCGG 1503 Silent TTT > TTC AID 298 G100C GGC > TGC GCCTA 395 Silent AAA > AAG 568 G190D GGC > GAC TGCCA 633 T212A ACG > GCG Rat APOBEC1 344 G155D GGC > GAC GGCCA 607 L203M CTG > ATG CCCTG 613 E205K GAG > AAG CTCGG 764 K255T AAG > ACG 987 Silent GGG > GGT TTCCC Human APOBEC1 669 Silent AGC > AGT AGCCG 758 R253H CGC > CAC TGCGC 841* Silent CTG > TTG AGCTG 697 H233D CAT > GAT TTCAT 699 H233D CAT > GAC 1149* Silent GCC > GCA GCCAT 1245* F415L TTT > TTG The region analyzed (encompassing exon 13 of BCR and exon 9 of ABL1) includes the imatinib-binding region of the fusion gene. The asterisk indicates mutations found in the same clone. The local sequence context for the mutations at cytosines is shown. Compared to the AID-induced mutations found in previous reports (mutations in approximately 30% of the sequences) [41], [42], we found approximately one mutation in each of the clones analyzed. This is explained by the different procedures we used to select resistant clones: whereas the other studies focused on competing bulk populations of AID-transfected GFP(+) cells and control GFP(−) cells, we analyzed individual clones arising from the same number of cells plated in the presence of imatinib. Please note that references 41 and 42 in the table legend correspond to the reference order in the original article [1].