For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
199
views
161
references
 Top references
cited by
249
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      175
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      A Historical Overview of Natural Products in Drug Discovery

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Historically, natural products have been used since ancient times and in folklore for the treatment of many diseases and illnesses. Classical natural product chemistry methodologies enabled a vast array of bioactive secondary metabolites from terrestrial and marine sources to be discovered. Many of these natural products have gone on to become current drug candidates. This brief review aims to highlight historically significant bioactive marine and terrestrial natural products, their use in folklore and dereplication techniques to rapidly facilitate their discovery. Furthermore a discussion of how natural product chemistry has resulted in the identification of many drug candidates; the application of advanced hyphenated spectroscopic techniques to aid in their discovery, the future of natural product chemistry and finally adopting metabolomic profiling and dereplication approaches for the comprehensive study of natural product extracts will be discussed.

          Related collections

          Most cited references161

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Detection of gene pathways with predictive power for breast cancer prognosis

          Shuangge Ma, Michael Kosorok (2010)
          Background Prognosis is of critical interest in breast cancer research. Biomedical studies suggest that genomic measurements may have independent predictive power for prognosis. Gene profiling studies have been conducted to search for predictive genomic measurements. Genes have the inherent pathway structure, where pathways are composed of multiple genes with coordinated functions. The goal of this study is to identify gene pathways with predictive power for breast cancer prognosis. Since our goal is fundamentally different from that of existing studies, a new pathway analysis method is proposed. Results The new method advances beyond existing alternatives along the following aspects. First, it can assess the predictive power of gene pathways, whereas existing methods tend to focus on model fitting accuracy only. Second, it can account for the joint effects of multiple genes in a pathway, whereas existing methods tend to focus on the marginal effects of genes. Third, it can accommodate multiple heterogeneous datasets, whereas existing methods analyze a single dataset only. We analyze four breast cancer prognosis studies and identify 97 pathways with significant predictive power for prognosis. Important pathways missed by alternative methods are identified. Conclusions The proposed method provides a useful alternative to existing pathway analysis methods. Identified pathways can provide further insights into breast cancer prognosis.
          Article 0 comments Cited 253 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Natural products: an evolving role in future drug discovery.

            Bhuwan Mishra, Vinod K Tiwari (2011)
            The therapeutic areas of infectious diseases and oncology have benefited from abundant scaffold diversity in natural products, able to interact with many specific targets within the cell and indeed for many years have been source or inspiration for the majority of FDA approved drugs. The present review describes natural products (NPs), semi-synthetic NPs and NP-derived compounds that have undergone clinical evaluation or registration from 2005 to 2010 by disease area i.e. infectious (bacterial, fungal, parasitic and viral), immunological, cardiovascular, neurological, inflammatory and related diseases and oncology. Copyright © 2011 Elsevier Masson SAS. All rights reserved.
            Article 0 comments Cited 190 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Drugs from the deep: marine natural products as drug candidates.

              Burkhard Haefner (2003)
              In recent years, marine natural product bioprospecting has yielded a considerable number of drug candidates. Most of these molecules are still in preclinical or early clinical development but some are already on the market, such as cytarabine, or are predicted to be approved soon, such as ET743 (Yondelis). Research into the ecology of marine natural products has shown that many of these compounds function as chemical weapons and have evolved into highly potent inhibitors of physiological processes in the prey, predators or competitors of the marine organisms that use them. Some of the natural products isolated from marine invertebrates have been shown to be, or are suspected to be, of microbial origin and this is now thought to be the case for the majority of such molecules. Marine microorganisms, whose immense genetic and biochemical diversity is only beginning to be appreciated, look likely to become a rich source of novel chemical entities for the discovery of more effective drugs.
              Article 0 comments Cited 178 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Metabolites
                Journal ID (iso-abbrev): Metabolites
                Journal ID (publisher-id): metabolites
                Title: Metabolites
                Publisher: MDPI
                ISSN (Electronic): 2218-1989
                Publication date (Electronic): 16 April 2012
                Publication date Collection: June 2012
                Volume: 2
                Issue: 2
                Pages: 303-336
                Affiliations
                [1 ]Metabolomics Australia, School of Botany, The University of Melbourne, Parkville, Victoria 3010, Australia
                [2 ]School of Applied Sciences (Discipline of Applied Chemistry), Health Innovations Research Institute (HIRi) RMIT University, G.P.O. Box 2476V, Melbourne, Victoria 3001, Australia
                [3 ]Australian Centre for Plant Functional Genomics, School of Botany, The University of Melbourne, Parkville, 3010, Victoria, Australia
                Author notes
                [* ] Author to whom correspondence should be addressed; E-mail: ddias@ 123456unimelb.edu.au ; Tel.: +61-3-8344-3318.
                Article
                Publisher ID: metabolites-02-00303
                DOI: 10.3390/metabo2020303
                PMC ID: 3901206
                PubMed ID: 24957513
                SO-VID: b902e3a4-9059-42c2-8466-0b3f6315ebb3
                Copyright © © 2012 by the authors; licensee MDPI, Basel, Switzerland.
                License:

                This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/3.0/).

                History
                Date received : 01 March 2012
                Date revision received : 31 March 2012
                Date accepted : 31 March 2012
                Categories
                Subject: Review

                Keywords: natural products,secondary metabolites,drug discovery,bioactivity,metabolomics,dereplication, plants,sponges,algae,fungi
                Data availability:
                Keywords: natural products, secondary metabolites, drug discovery, bioactivity, metabolomics, dereplication, plants, sponges, algae, fungi

                Comments

                Comment on this article

                scite_

                Similar content175

                See all similar

                Cited by408

                See all cited by

                Most referenced authors1,850

                See all reference authors