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Effects of hyperventilation and hypocapnic/normocapnic hypoxemia on renal function and lithium clearance in humans.
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Abstract
Using the renal clearance of lithium as an index of proximal tubular outflow, this study tested the hypothesis that acute hypocapnic hypoxemia decreases proximal tubular reabsorption to the same extent as hypocapnic normoxemia (hyperventilation) and that this response is blunted during normocapnic hypoxemia.