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      The virome in mammalian physiology and disease.

      Cell

      Animals, Bacteria, virology, Bacteriophages, classification, genetics, physiology, Host-Pathogen Interactions, Humans, Mammals, immunology, Microbiota, Viruses, metabolism

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          Abstract

          The virome contains the most abundant and fastest mutating genetic elements on Earth. The mammalian virome is constituted of viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect the broad array of other types of organisms that inhabit us. Virome interactions with the host cannot be encompassed by a monotheistic view of viruses as pathogens. Instead, the genetic and transcriptional identity of mammals is defined in part by our coevolved virome, a concept with profound implications for understanding health and disease. Copyright © 2014 Elsevier Inc. All rights reserved.

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          Journal
          24679532
          3977141
          10.1016/j.cell.2014.02.032

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