Blog
About

68
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Quantum dot bioconjugates for ultrasensitive nonisotopic detection.

      Science (New York, N.Y.)

      Cadmium Compounds, chemistry, Zinc Compounds, metabolism, Transferrin, Sulfides, Solubility, Semiconductors, Selenium Compounds, Receptors, Transferrin, Particle Size, Molecular Probe Techniques, Luminescence, Humans, HeLa Cells, Fluorescent Dyes, Fluorescent Antibody Technique, Endocytosis

      Read this article at

      ScienceOpenPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection. In comparison with organic dyes such as rhodamine, this class of luminescent labels is 20 times as bright, 100 times as stable against photobleaching, and one-third as wide in spectral linewidth. These nanometer-sized conjugates are water-soluble and biocompatible. Quantum dots that were labeled with the protein transferrin underwent receptor-mediated endocytosis in cultured HeLa cells, and those dots that were labeled with immunomolecules recognized specific antibodies or antigens.

          Related collections

          Author and article information

          Journal
          9748158

          Comments

          Comment on this article