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      Beyond oxidative stress: an immunologist's guide to reactive oxygen species.

      Nature reviews. Immunology

      Adaptive Immunity, immunology, Reactive Oxygen Species, Immunity, Innate, Humans, Homeostasis, Animals

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          Abstract

          Reactive oxygen species (ROS) react preferentially with certain atoms to modulate functions ranging from cell homeostasis to cell death. Molecular actions include both inhibition and activation of proteins, mutagenesis of DNA and activation of gene transcription. Cellular actions include promotion or suppression of inflammation, immunity and carcinogenesis. ROS help the host to compete against microorganisms and are also involved in intermicrobial competition. ROS chemistry and their pleiotropy make them difficult to localize, to quantify and to manipulate - challenges we must overcome to translate ROS biology into medical advances.

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          Author and article information

          Journal
          23618831
          10.1038/nri3423
          4250048

          Chemistry

          Adaptive Immunity, immunology, Reactive Oxygen Species, Immunity, Innate, Humans, Homeostasis, Animals

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