280
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Microenvironmental regulation of tumor progression and metastasis

      ,
      Nature Medicine
      Springer Science and Business Media LLC

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Cancers develop in complex tissue environments, which they depend on for sustained growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor microenvironment (TME) are genetically stable and thus represent an attractive therapeutic target with reduced risk of resistance and tumor recurrence. However, specifically disrupting the pro-tumorigenic TME is a challenging undertaking, as the TME has diverse capacities to induce both beneficial and adverse consequences for tumorigenesis. Furthermore, many studies have shown that the microenvironment is capable of normalizing tumor cells, suggesting that re-education of stromal cells, rather than targeted ablation per se, may be an effective strategy for treating cancer. Here we discuss the paradoxical roles of the TME during specific stages of cancer progression and metastasis, as well as recent therapeutic attempts to re-educate stromal cells within the TME to have anti-tumorigenic effects.

          Related collections

          Author and article information

          Journal
          Nature Medicine
          Nat Med
          Springer Science and Business Media LLC
          1078-8956
          1546-170X
          November 2013
          November 7 2013
          November 2013
          : 19
          : 11
          : 1423-1437
          Article
          10.1038/nm.3394
          3954707
          24202395
          d20bf2b0-aa12-4aa7-abf7-1de128a6f4d2
          © 2013

          http://www.springer.com/tdm

          History

          Comments

          Comment on this article