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Abstract
A total of 296 volunteers in five different groups were immunized with one dose of
the commercial 1991-1992 trivalent split influenza vaccine formulation A/Singapore/6/86
(H1N1), A/Beijing/353/89 (H3N2) and B/Yamagata/16/88. The groups differed in age (young
adults, middle-aged and elderly) and history of previous vaccination. Antibodies were
determined in pre- and postvaccination sera by haemagglutination inhibition assay
and the results were evaluated as geometric mean titre, mean fold antibody increase,
protection and response rates. No significant age-related differences among the protection
rates were found. The proportion of vaccinees with antibodies > or = 40 ranged between
70 and 95%. Compared with the H3N2 and B components the antibody response to the H1N1-component
was low. Residents of a nursing home fully vaccinated the previous year developed
7.6-8.4-fold antibody increases and showed 96-100% protection rates.