Frequent aerogenous spread with decreased E-cadherin expression of ROS1- rearranged lung cancer predicts poor disease-free survival

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Abstract

ROS1 rearrangement has been found in a subset of lung cancer and ROS1-rearranged tumors are sensitive to ALK kinase inhibitors. This study sought to evaluate the clinicopathological implications and histomorphological characteristics of ROS1-rearranged tumors, especially micropapillary and aerogenous spread growth and to investigate the usefulness of ROS1 immunohistochemistry as a diagnostic test for ROS1 rearrangement.

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Journal

Title: Lung Cancer

Abbreviated Title: Lung Cancer

Publisher: Elsevier BV

ISSN (Print): 01695002

Publication date Created: September 2015

Publication date (Print): September 2015

Volume: 89

Issue: 3

Pages: 343-349

Article

DOI: 10.1016/j.lungcan.2015.06.012

PubMed ID: 26149475

SO-VID: d9165059-33ff-43f5-8126-045df95f79c7

License:

https://www.elsevier.com/tdm/userlicense/1.0/

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