For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
1
views
36
references
 Top references
cited by
0
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      304
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Sensitization to Furry Animals in Patients with Suspected Allergic Disease in China: A Multicenter Study

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Purpose

          An objective of this study was to investigate the allergen sensitization characteristics of cat, dog and horse dander in patients with suspected allergic diseases in different geographical regions of Chinese mainland.

          Patients and Methods

          We invited 2377 patients aged 0–86 years with suspected allergic diseases to participate in a cross-sectional survey in 11 provinces in China. Combined with the questionnaires and animal-specific IgE levels, we analyzed the epidemiological characteristics and risk factors of furry animal sensitization in different regions and populations of Chinese Mainland.

          Results

          Among the 2377 patients with suspected allergic diseases, 14.9% were sensitized to cat dander, 9.3% to dog dander and 5.5% to horse dander. Animal allergens mainly cause low-level sensitization (class 1–3). There was a significant correlation between cat, dog and horse dander allergen sIgE, with correlation coefficients (r s) all greater than 0.750. The majority (46.5%) of sIgE-positive patients were sensitized to at least two animal allergens simultaneously. The prevalence of these animals all showed a trend of increasing first and then decreasing with age, and all reached the peak in young adolescence. As for the geographical factors, the sensitization rate of cats and dogs in Western was significantly higher than that in Eastern (cat: 18.4% vs 9.2%, dog: 11.6% vs 5.5%, all P < 0.001), however, no significant differences were found in horses. Aged ≤6 years, living in Western, and high animal allergen exposure elevated the risk of cat or dog sensitization. Living on a lower floor (aOR: 0.56) was a protective factor for horse sensitization.

          Conclusion

          In this representative sample of Chinese patients with suspected allergic diseases, there was an apparent geographic variation in sensitization to cats and dogs. Age factor and living in Western also had a significant impact on animal allergen sensitization rate.

          Related collections

          Most cited references36

          • Record: found
          • Abstract: not found
          • Article: not found

          Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen).

          J. Bousquet, N Khaltaev, A Cruz … (2008)
          Article 0 comments Cited 434 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found
            Is Open Access

            World allergy organization anaphylaxis guidance 2020

            Victoria Cardona, Ignacio J. Ansotegui, Motohiro Ebisawa … (2020)
            Anaphylaxis is the most severe clinical presentation of acute systemic allergic reactions. The occurrence of anaphylaxis has increased in recent years, and subsequently, there is a need to continue disseminating knowledge on the diagnosis and management, so every healthcare professional is prepared to deal with such emergencies. The rationale of this updated position document is the need to keep guidance aligned with the current state of the art of knowledge in anaphylaxis management. The World Allergy Organization (WAO) anaphylaxis guidelines were published in 2011, and the current guidance adopts their major indications, incorporating some novel changes. Intramuscular epinephrine (adrenaline) continues to be the first-line treatment for anaphylaxis. Nevertheless, its use remains suboptimal. After an anaphylaxis occurrence, patients should be referred to a specialist to assess the potential cause and to be educated on prevention of recurrences and self-management. The limited availability of epinephrine auto-injectors remains a major problem in many countries, as well as their affordability for some patients.
            Article 0 comments Cited 193 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              EAACI Molecular Allergology User's Guide.

              P Matricardi, J Kleine-Tebbe, H Hoffmann … (2016)
              The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.
              Article 0 comments Cited 152 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): J Asthma Allergy
                Journal ID (iso-abbrev): J Asthma Allergy
                Journal ID (publisher-id): jaa
                Title: Journal of Asthma and Allergy
                Publisher: Dove
                ISSN (Electronic): 1178-6965
                Publication date (Electronic): 24 November 2022
                Publication date Collection: 2022
                Volume: 15
                Pages: 1701-1712
                Affiliations
                [1 ]Department of Allergy and Clinical Immunology, Department of Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou, 510120, People’s Republic of China
                [2 ]Department of Pediatrics, Boai Hospital of Zhongshan City , Zhongshan, 528400, People’s Republic of China
                [3 ]Department of Respirology, Children’s Hospital, Soochow University , Suzhou, 215025, People’s Republic of China
                Author notes
                Correspondence: Baoqing Sun; Wenting Luo, Department of Allergy and Clinical Immunology, Department of Laboratory, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University , 151 Yanjiangxi Road, Guangzhou, 510120, Guangdong, People’s Republic of China, Tel +86 20 8306 2865, Fax +86 20 8306 2729, Email sunbaoqing@vip.163.com; 348307379@qq.com
                [*]

                These authors contributed equally to this work

                Author information
                http://orcid.org/0000-0002-8543-3192
                http://orcid.org/0000-0001-5975-0672
                http://orcid.org/0000-0002-7379-7183
                http://orcid.org/0000-0002-1671-0723
                Article
                Publisher ID: 390473
                DOI: 10.2147/JAA.S390473
                PMC ID: 9704004
                PubMed ID: 36452936
                SO-VID: da6f2a8c-e7bb-4851-9dd2-e0c12476473b
                Copyright © © 2022 Zhu et al.
                License:

                This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms ( https://www.dovepress.com/terms.php).

                History
                Date received : 27 September 2022
                Date accepted : 11 November 2022
                Page count
                Figures: 5, Tables: 1, References: 37, Pages: 12
                Funding
                Funded by: Guangzhou Science and Technology Program;
                Funded by: Guangdong Zhongnanshan Medical Foundation;
                This study was supported by Guangzhou Science and Technology Program (202102010327) and Guangdong Zhongnanshan Medical Foundation (ZNSXS-20220011).
                Categories
                Subject: Original Research

                ScienceOpen disciplines: Immunology
                Keywords: animal allergen,specific immunoglobulin e,cross-sectional survey,suspected allergic patient
                Data availability:
                ScienceOpen disciplines: Immunology
                Keywords: animal allergen, specific immunoglobulin e, cross-sectional survey, suspected allergic patient

                Comments

                Comment on this article