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Abstract
Controlled drug delivery technology has progressed over the last six decades. This
progression began in 1952 with the introduction of the first sustained release formulation.
The 1st generation of drug delivery (1950-1980) focused on developing oral and transdermal
sustained release systems and establishing controlled drug release mechanisms. The
2nd generation (1980-2010) was dedicated to the development of zero-order release
systems, self-regulated drug delivery systems, long-term depot formulations, and nanotechnology-based
delivery systems. The latter part of the 2nd generation was largely focused on studying
nanoparticle formulations. The Journal of Controlled Release (JCR) has played a pivotal
role in the 2nd generation of drug delivery technologies, and it will continue playing
a leading role in the next generation. The best path towards a productive 3rd generation
of drug delivery technology requires an honest, open dialog without any preconceived
ideas of the past. The drug delivery field needs to take a bold approach to designing
future drug delivery formulations primarily based on today's necessities, to produce
the necessary innovations. The JCR provides a forum for sharing the new ideas that
will shape the 3rd generation of drug delivery technology.